Weekly topotecan for recurrent endometrial cancer: A case series and review of the literature Journal Article
| Authors: | Traina, T. A.; Sabbatini, P.; Aghajanian, C.; Dupont, J. |
| Article Title: | Weekly topotecan for recurrent endometrial cancer: A case series and review of the literature |
| Abstract: | Topotecan, a topoisomerase 1 inhibitor, has demonstrated antitumor activity in ovarian and endometrial cancers when administered daily for 5 days every 3 weeks. Recently, topotecan has been studied on a weekly dosing schedule for the treatment of ovarian cancer and found to have efficacy with reduced toxicity. The aim of this study is to review the Memorial Sloan-Kettering Cancer Center (MSKCC) experience with weekly topotecan dosing in women with recurrent endometrial cancer. We have included a review of the literature of weekly topotecan in the treatment of patients with gynecologic cancer. After Institutional Review Board (IRB) approval, we identified all women with recurrent endometrial cancer treated with topotecan at MSKCC from May 1996 to February 2004. Patients treated on a weekly schedule were assessed for toxicity and response. A review of the literature pertaining to weekly topotecan in the treatment of endometrial cancer was also performed. Eleven patients were treated with weekly topotecan during the study period, with doses ranging from 2.5-4.0 mg/m 2 on a 2- or 3-week schedule with 1 week off. The median age of the patients was 60 years old (range, 47-76 years), and the median Karnofsky performance status was 80%. Six of the 11 patients were previously treated with more than three chemotherapy regimens and eight had received prior pelvic radiation. Ninety-seven percent of treatment doses were delivered as scheduled, and only two patients required dose reductions. One patient achieved a prolonged partial response for 54 weeks, and two patients had stabilization of disease for 15 weeks each. Weekly topotecan has antitumor activity and is well tolerated in patients with recurrent endometrial cancer, including those patients with multiple prior treatments. Topotecan on a weekly bolus schedule should be evaluated in prospective trials to better establish its role in the treatment of recurrent endometrial cancer. © 2004 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; aged; middle aged; cancer surgery; clinical trial; drug tolerability; fatigue; neutropenia; review; doxorubicin; dose response; drug dose reduction; side effect; antineoplastic agents; paclitaxel; topotecan; endometrial cancer; cancer diagnosis; endometrial neoplasms; endometrium cancer; carboplatin; neoplasm recurrence, local; anemia; bone marrow suppression; bleeding; blood toxicity; leukopenia; nausea; thrombocytopenia; drug administration schedule; antineoplastic activity; gastrointestinal toxicity; enzyme inhibitors; literature; recurrent disease; sepsis; alopecia; dna topoisomerases, type i; humans; prognosis; human; female; priority journal; topoisomerase inhibitor; weekly administration |
| Journal Title: | Gynecologic Oncology |
| Volume: | 95 |
| Issue: | 1 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-10-01 |
| Start Page: | 235 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2004.07.035 |
| PROVIDER: | scopus |
| PUBMED: | 15385138 |
| DOI/URL: | |
| Notes: | Gynecol. Oncol. -- Cited By (since 1996):12 -- Export Date: 16 June 2014 -- CODEN: GYNOA -- Source: Scopus |
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253Traina -
612Aghajanian
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