Retrospective study of the hepatic safety profile of patients concomitantly treated with caspofungin and cyclosporin A Journal Article
| Authors: | Marr, K. A.; Hachem, R.; Papanicolaou, G.; Somani, J.; Arduino, J. M.; Lipka, C. J.; Ngai, A. L.; Kartsonis, N.; Chodakewitz, J.; Sable, C. A. |
| Article Title: | Retrospective study of the hepatic safety profile of patients concomitantly treated with caspofungin and cyclosporin A |
| Abstract: | Background. Mild, transient alanine aminotransferase (ALT) elevations were seen in Phase I studies of caspofungin and cyclosporin A (CsA). Methods. We conducted a retrospective chart review at four sites to characterize the hepatic safety in patients receiving ≥1 day of both drugs over a 20-month period. Investigators assessed reasons for discontinuing concomitant therapy and the presence/etiology of any hepatotoxicity. Results. Forty patients receiving concomitant therapy for 1-290 days (median 17.5 days) were identified. Although common, liver enzyme abnormalities were frequently attributed to other comorbidities or medications. ALT and/or aspartate aminotransferase (AST) elevations occurred in 14 patients (35%). Five had ASTelevations at least possibly related to caspofungin/CsA, but none were >3.6 times the normal upper limit. No ALTelevations were related to caspofungin/CsA. Two of 4 patients had discontinuation of therapy because of hepatotoxicity possibly related to caspofungin/CsA. No serious adverse events occurred because of caspofungin. Conclusions. These data do not suggest a significant risk of clinically relevant hepatotoxicity with concomitant caspofungin/CsA. |
| Keywords: | adolescent; adult; child; clinical article; aged; middle aged; retrospective studies; review; drug withdrawal; liver toxicity; drug administration schedule; hematopoietic stem cell transplantation; retrospective study; alanine aminotransferase; aspartate aminotransferase; liver; drug therapy, combination; comorbidity; liver diseases; liver enzyme; cyclosporin a; levofloxacin; caspofungin; fluconazole; cyclosporine; immunosuppressive agents; voriconazole; antifungal agents; peptides, cyclic; itraconazole; hepatotoxicity; aspartate aminotransferases; alanine transaminase; humans; human; male; female; priority journal |
| Journal Title: | Transplant Infectious Disease |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 1398-2273 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2004-09-01 |
| Start Page: | 110 |
| End Page: | 116 |
| Language: | English |
| DOI: | 10.1111/j.1399-3062.2004.00065.x |
| PROVIDER: | scopus |
| PUBMED: | 15569226 |
| DOI/URL: | |
| Notes: | Transplant Infect. Dis. -- Cited By (since 1996):77 -- Export Date: 16 June 2014 -- CODEN: TIDSF -- Source: Scopus |
