Immune recognition of self in immunity against cancer Journal Article
| Authors: | Houghton, A. N.; Guevara-Patiño, J. A. |
| Article Title: | Immune recognition of self in immunity against cancer |
| Abstract: | Most antigens expressed by human cancer cells and recognized by host T cells and antibodies are nonmutated self antigens - molecules also expressed on the surface of normal cells. These self antigens are ineffective at triggering immune responses against cancer cells, which provides one explanation for the difficulties in trying to immunize against human cancer. A new study describes how tumors can avoid recognition by the immune system and how enhancing the affinity of the interaction between a self antigen and the MHC-I molecule may lead to cancer immunity (see the article beginning on page 551). |
| Keywords: | genetics; review; note; neoplasm; neoplasms; antigen expression; t lymphocyte; t-lymphocytes; animal; animals; biological model; peptide; tumor antigen; immunological tolerance; immunology; antigens, neoplasm; immunogenicity; cancer cell; antigen recognition; peptides; autoantigen; autoantigens; tumor immunity; molecular interaction; pathogenicity; major histocompatibility complex; antibodies, neoplasm; host cell; bacterium; cell mutant; major histocompatibility antigen class 1; self tolerance; cancer antibody; bacteria; models, immunological; humans; human; priority journal |
| Journal Title: | Journal of Clinical Investigation |
| Volume: | 114 |
| Issue: | 4 |
| ISSN: | 0021-9738 |
| Publisher: | American Society for Clinical Investigation |
| Date Published: | 2004-08-01 |
| Start Page: | 468 |
| End Page: | 471 |
| Language: | English |
| DOI: | 10.1172/jci22685 |
| PROVIDER: | scopus |
| PMCID: | PMC503781 |
| PUBMED: | 15314682 |
| DOI/URL: | |
| Notes: | J. Clin. Invest. -- Cited By (since 1996):53 -- Export Date: 16 June 2014 -- CODEN: JCINA -- Source: Scopus |
