Platelets and metastasis revisited: A novel fatty link Journal Article
| Authors: | Gupta, G. P.; Massagué, J. |
| Article Title: | Platelets and metastasis revisited: A novel fatty link |
| Abstract: | Platelets have long been suspected of having a role in cancer progression and metastasis that has largely been attributed to platelet-mediated enhancement of tumor cell survival, extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a tumor cell mitogen and promoter of osteolysis during bone metastasis (see the related article beginning on page 1714). |
| Keywords: | osteolysis; disease course; review; cancer growth; nonhuman; note; bone metastasis; ovarian neoplasms; metabolism; cell survival; metastasis; ovary cancer; thrombocyte; breast cancer; biological model; models, biological; pathology; cell line, tumor; angiogenesis; breast neoplasms; neovascularization, pathologic; physiology; disease progression; breast tumor; ovary tumor; tumor cell line; bone; neoplasm metastasis; metastasis potential; bone and bones; neovascularization (pathology); thrombocyte activation; blood platelets; lysophospholipids; lysophospholipid; lysophosphatidic acid; humans; human; female; priority journal |
| Journal Title: | Journal of Clinical Investigation |
| Volume: | 114 |
| Issue: | 12 |
| ISSN: | 0021-9738 |
| Publisher: | American Society for Clinical Investigation |
| Date Published: | 2004-12-01 |
| Start Page: | 1691 |
| End Page: | 1693 |
| Language: | English |
| DOI: | 10.1172/jci200423823 |
| PROVIDER: | scopus |
| PMCID: | PMC535073 |
| PUBMED: | 15599391 |
| DOI/URL: | |
| Notes: | J. Clin. Invest. -- Cited By (since 1996):73 -- Export Date: 16 June 2014 -- CODEN: JCINA -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work