Head and neck soft tissue sarcomas: A multivariate analysis of outcomes Journal Article

  


Authors: Bentz, B. G.; Singh, B.; Woodruff, J.; Brennan, M.; Shah, J. P.; Kraus, D.
Article Title: Head and neck soft tissue sarcomas: A multivariate analysis of outcomes
Abstract: Background: Soft tissue sarcomas of the head and neck region represent a rare group of tumors of which a limited number of published individual- and institution-based experiences exist. Methods: We performed an analysis of head and neck sarcoma patients identified from our institution between 1973 and 1999. Exclusion criteria included pediatric rhabdomyosarcomas, sarcomas of the neuromeningeal axis or non-head and neck primary disease sites, and bone sarcomas. All cases underwent pathologic re-review before statistical analysis. Results: After pathologic review, 111 head and neck sarcoma patients remained (mean age, 47 ± 20 years). The median duration of follow-up was 51 months; the actuarial 5-year relapse-free, disease-specific, and overall survivals were 55%, 52%, and 44%, respectively. Forty-six percent remained free of recurrence at the most recent follow-up, and the most common site of recurrence was local followed by distant sites. By multivariate analysis, size and grade significantly influenced relapse-free, disease-specific, and overall survivals, whereas margin status additionally influenced relapse-free survival. Subset analysis of the fibrosarcoma/malignant fibrous histiocytoma and desmoid/dermatofibrosarcoma protuberans histologies was undertaken. Conclusions: Size >5 cm and high-grade histology are considered poor prognostic indicators. Patients with either of these characteristics should be considered for adjuvant trials. © 2004 The Society of Surgical Oncology, Inc.
Keywords: osteosarcoma; adult; cancer survival; controlled study; treatment outcome; aged; disease-free survival; middle aged; survival rate; major clinical study; mortality; review; cancer localization; cancer recurrence; united states; disease free survival; follow up; follow-up studies; antineoplastic agent; cancer grading; pathology; histology; sarcoma; statistical analysis; statistical significance; fibrosarcoma; head and neck cancer; head and neck neoplasms; cancer size; outcomes research; new york city; multivariate analysis; dermatofibroma; malignant fibrous histiocytoma; rhabdomyosarcoma; head and neck; soft tissue neoplasms; soft tissue tumor; head and neck tumor; pediatrics; desmoid tumor; dermatofibrosarcoma; dermatofibrosarcoma protuberans; fibromatosis; fibromatosis, aggressive; single institution; soft tissue cancer; histiocytoma, benign fibrous; retrospective; humans; prognosis; human; male; female; article
Journal Title: Annals of Surgical Oncology
Volume: 11
Issue: 6
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2004-06-01
Start Page: 619
End Page: 628
Language: English
DOI: 10.1245/aso.2004.03.006
PROVIDER: scopus
PUBMED: 15172935
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-4043063443&partnerID=40&md5=bdb7cf857388fec59e5c2ba5b7a0e882
Notes: Ann. Surg. Oncol. -- Cited By (since 1996):39 -- Export Date: 16 June 2014 -- CODEN: ASONF -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. Dennis Kraus
    268 Kraus
  3. Bhuvanesh Singh
    242 Singh
  4. Jatin P Shah
    722 Shah
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