ATRX: Put me on repeat Journal Article
| Authors: | Whitehouse, I.; Owen-Hughes, T. |
| Article Title: | ATRX: Put me on repeat |
| Abstract: | Mutations in the chromatin-remodeling protein ATRX cause alpha thalassaemia and mental retardation, but the severity of the disorder is independent of the specific mutation. In this issue of Cell, Law et al. (2010) demonstrate that ATRX alters gene expression by binding to G-rich tandem repeats, and the degree of transcriptional silencing caused by ATRX mutations correlates with the number of repeats. © 2010 Elsevier Inc. |
| Keywords: | unclassified drug; gene mutation; nonhuman; gene expression; disease severity; short survey; dna sequence; gene silencing; helicase; guanine nucleotide binding protein; chromatin structure; alpha thalassemia; mental deficiency; daxx protein; protein atrx; tandem repeat |
| Journal Title: | Cell |
| Volume: | 143 |
| Issue: | 3 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2010-10-29 |
| Start Page: | 335 |
| End Page: | 336 |
| Language: | English |
| DOI: | 10.1016/j.cell.2010.10.021 |
| PROVIDER: | scopus |
| PUBMED: | 21029854 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: CELLB" - "Source: Scopus" |
