Monophasic synovial sarcoma: A cytologic spectrum Journal Article
| Authors: | Ewing, C. A.; Zakowski, M. F.; Lin, O. |
| Article Title: | Monophasic synovial sarcoma: A cytologic spectrum |
| Abstract: | Synovial sarcoma (SS) is a high-grade sarcoma that can be diagnosed in cytology with certainty only when it presents with a biphasic pattern. Monophasic SS (MSS), however, is a diagnostic consideration when a uniform spindle cell population is present. The purpose of this study was to evaluate a series of cytologic cases of MSS and its cytologic presentation. Twenty-one FNAs of histologically confirmed MSS were reviewed. Specimens consisted of tissue fragments and single cells containing scant granular cytoplasm, medium-sized nuclei, and coarse chromatin. A monotonous spindle pattern with comma-shaped nuclei was present in 5 cases. Sixteen cases contained oval and spindled nuclei. Eight of these specimens contained round nuclei, and 5 of these cases showed prominent nucleoli and cohesive clusters, reminiscent of biphasic SS. We conclude that a spectrum of cytologic findings can be seen in MSS, including a secondary population of cells with morphology usually typical of biphasic SS. © 2004 Wiley-Liss. Inc. |
| Keywords: | immunohistochemistry; adult; controlled study; human tissue; aged; middle aged; retrospective studies; clinical feature; histopathology; cytology; microscopy, electron; diagnosis, differential; sarcoma; cancer cytodiagnosis; reverse transcriptase polymerase chain reaction; biopsy, fine-needle; cytoplasm; translocation, genetic; spindle cell; cell nucleus; synovial sarcoma; sarcoma, synovial; aspiration biopsy; cytopathology; soft tissue neoplasms; chromatin structure; nucleolus; aspiration cytology; fine-needle aspiration; humans; human; male; female; priority journal; article; monophasic |
| Journal Title: | Diagnostic Cytopathology |
| Volume: | 30 |
| Issue: | 1 |
| ISSN: | 8755-1039 |
| Publisher: | Wiley Liss |
| Date Published: | 2004-01-01 |
| Start Page: | 19 |
| End Page: | 23 |
| Language: | English |
| DOI: | 10.1002/dc.10413 |
| PROVIDER: | scopus |
| PUBMED: | 14696140 |
| DOI/URL: | |
| Notes: | Diagn. Cytopathol. -- Cited By (since 1996):10 -- Export Date: 16 June 2014 -- CODEN: DICYE -- Source: Scopus |
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