Total synthesis of aigialomycin D Journal Article
| Authors: | Geng, X.; Danishefsky, S. J. |
| Article Title: | Total synthesis of aigialomycin D |
| Abstract: | (Matrix presented) The first total synthesis of resorcinylic macrolide aigialomycin D was described. The resorcinylic moiety was constructed by a highly efficient Diels Alder reaction using a disiloxydiene and a 14-membered "ynolide" as the dienophile synthesized by ring-forming olefin metathesis. |
| Keywords: | unclassified drug; antineoplastic agent; drug structure; drug synthesis; cyclopropanes; molecular structure; antimalarial agent; macrolide; diels alder reaction; ring closing metathesis; stereoisomerism; alkadiene; lactones; macrolides; article; aigialomycin d |
| Journal Title: | Organic Letters |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 1523-7060 |
| Publisher: | American Chemical Society |
| Date Published: | 2004-02-05 |
| Start Page: | 413 |
| End Page: | 416 |
| Language: | English |
| DOI: | 10.1021/ol036258m |
| PROVIDER: | scopus |
| PUBMED: | 14748606 |
| DOI/URL: | |
| Notes: | Org. Lett. -- Cited By (since 1996):52 -- Export Date: 16 June 2014 -- Source: Scopus |
