A common prostate cancer risk variant 5′ of Microseminoprotein-β (MSMB) is a strong predictor of circulating β-microseminoprotein (MSP) levels in multiple populations Journal Article
| Authors: | Waters, K. M.; Stram, D. O.; Le Marchand, L.; Klein, R. J.; Valtonen-André, C.; Peltola, M. T.; Kolonel, L. N.; Henderson, B. E.; Lilja, H.; Haiman, C. A. |
| Article Title: | A common prostate cancer risk variant 5′ of Microseminoprotein-β (MSMB) is a strong predictor of circulating β-microseminoprotein (MSP) levels in multiple populations |
| Abstract: | Background: β-Microseminoprotein (MSP) is one of the three most abundantly secreted proteins of the prostate and has been suggested as a biomarker for prostate cancer risk. A common variant, rs10993994, in the 5′ region of the gene that encodes MSP (MSMB) has recently been identified as a risk factor for prostate cancer. Methods: We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans). Generalized linear models were used to estimate the association between rs10993994 genotype and MSP levels. Results: We observed robust associations between rs10994994 genotype and MSP levels in each racial/ethnic population (all P < 10-8), with carriers of the C allele having lower geometric mean MSP levels (ng/mL; CC/CT/TT genotypes: European Americans, 28.8/20.9/10.0; African Americans, 29.0/21.9/10.9; Latinos, 29.2/17.1/8.3; and Japanese Americans, 25.8/16.4/6.7). We estimated the variant accounts for 30% to 50% of the variation in MSP levels in each population. We also observed significant differences in MSP levels between populations (P = 3.5 × 10-6), with MSP levels observed to be highest in African Americans and lowest in Japanese Americans. Conclusions: Rs10993994 genotype is strongly associated with plasma MSP levels in multiple racial/ethnic populations. Impact: This supports the hypothesis that rs10993994 may be the biologically functional allele. ©2010 AACR. |
| Keywords: | adult; aged; middle aged; major clinical study; cancer risk; genetic predisposition to disease; cohort studies; tumor markers, biological; genotype; gene frequency; prostate cancer; prostatic neoplasms; race difference; ethnic group; african american; european american; hispanic; asian american; continental population groups; beta microseminoprotein; prostatic secretory proteins |
| Journal Title: | Cancer Epidemiology Biomarkers and Prevention |
| Volume: | 19 |
| Issue: | 10 |
| ISSN: | 1055-9965 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2010-10-01 |
| Start Page: | 2639 |
| End Page: | 2646 |
| Language: | English |
| DOI: | 10.1158/1055-9965.epi-10-0427 |
| PUBMED: | 20736317 |
| PROVIDER: | scopus |
| PMCID: | PMC3041671 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: CEBPE" - "Source: Scopus" |
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