Identification of virus-encoded microRNAs Journal Article
| Authors: | Pfeffer, S.; Zavolan, M.; Grässer, F. A.; Chien, H.; Russo, J. J.; Ju, J.; John, B.; Enright, A. J.; Marks, D.; Sander, C.; Tuschl, T. |
| Article Title: | Identification of virus-encoded microRNAs |
| Abstract: | RNA silencing processes are guided by small RNAs that are derived from double-stranded RNA. To probe for function of RNA silencing during infection of human cells by a DNA virus, we recorded the small RNA profile of cells infected by Epstein-Barr virus (EBV). We show that EBV expresses several microRNA (miRNA) genes. Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or viral gene expression. |
| Keywords: | controlled study; human cell; dna-binding proteins; nonhuman; proteins; animals; infection; genes; microrna; gene expression; biology; computational biology; cell line; rna interference; cell line, tumor; animalia; rna; gene expression regulation; cloning, molecular; regulatory mechanism; dna viruses; rna, messenger; gene silencing; micrornas; virus latency; genetic code; epstein barr virus; rna, viral; herpesvirus 4, human; double stranded rna; host; rna, double-stranded; viral proteins; degradation; dna-directed dna polymerase; virus gene; human herpesvirus 4; viruses; dna virus; untranslated regions; rna silencing; humans; human; priority journal; article; epstein-barr viruses (ebv); viral regulators; callithrix |
| Journal Title: | Science |
| Volume: | 304 |
| Issue: | 5671 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2004-04-30 |
| Start Page: | 734 |
| End Page: | 736 |
| Language: | English |
| DOI: | 10.1126/science.1096781 |
| PROVIDER: | scopus |
| PUBMED: | 15118162 |
| DOI/URL: | |
| Notes: | Science -- Cited By (since 1996):723 -- Export Date: 16 June 2014 -- CODEN: SCIEA -- Source: Scopus |
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