Adverse prognostic significance of CD20 positive Reed-Sternberg cells in classical Hodgkin's disease Journal Article
| Authors: | Portlock, C. S.; Donnelly, G. B.; Qin, J.; Straus, D.; Yahalom, J.; Zelenetz, A.; Noy, A.; O'connor, O.; Horwitz, S.; Moskowitz, C.; Filippa, D. A. |
| Article Title: | Adverse prognostic significance of CD20 positive Reed-Sternberg cells in classical Hodgkin's disease |
| Abstract: | The prognostic significance of CD20 positive classical Hodgkin's disease (cHD) is uncertain. All cHD cases referred to the Memorial Sloan-Kettering Cancer Center (MSKCC) were retrospectively identified (5/92-11/00); the samples were immunostained, and clinical data ascertained. Cases were re-reviewed without knowledge of clinical outcome. Univariate and multivariate analyses were performed 248 patients had cHD: 28 CD20+ (11%); 220 CD20 -. All clinical characteristics were comparable except haemoglobin level at presentation. With a median follow-up of 29.2 months, significant prognostic factors in multivariate analysis were: CD20 positivity, elevated white blood cell count (WBC) and low absolute lymphocyte count for time-to treatment failure (TTF); and for overall survival (OS), CD20 positivity, elevated WBC count, bone marrow involvement and age ≥45 years. TTF was significantly poorer for ABVD-treated patients with CD20+ cHD as compared with CD20- cHD. Among 167 patients treated at MSKCC, both TTF (P < 0.0001) and OS (P = 0.017) were significantly decreased in CD20 + patients as compared with CD20- cHD. CD20+ cHD is a poor prognostic factor for TTF and OS. All cHD cases should be immunophenotyped for CD20. A large prospective trial is needed to confirm these findings. © 2004 Blackwell Publishing Ltd. |
| Keywords: | immunohistochemistry; survival; adolescent; adult; child; controlled study; aged; middle aged; survival rate; treatment failure; major clinical study; prednisone; doxorubicin; methotrexate; follow up; biological markers; dacarbazine; etoposide; cyclophosphamide; hemoglobin; vincristine; retrospective study; chlormethine; procarbazine; vinblastine; hodgkin disease; vincristine sulfate; cd20; cd20 antigen; antigens, cd20; bleomycin; immunophenotyping; multivariate analysis; leukocyte count; leukocyte; lymphocyte count; reed sternberg cell; reed-sternberg cells; immunophenotype; humans; prognosis; human; male; female; priority journal; article; classical hodgkin's disease |
| Journal Title: | British Journal of Haematology |
| Volume: | 125 |
| Issue: | 6 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2004-06-01 |
| Start Page: | 701 |
| End Page: | 708 |
| Language: | English |
| DOI: | 10.1111/j.1365-2141.2004.04964.x |
| PROVIDER: | scopus |
| PUBMED: | 15180859 |
| DOI/URL: | |
| Notes: | Br. J. Haematol. -- Cited By (since 1996):33 -- Export Date: 16 June 2014 -- CODEN: BJHEA -- Source: Scopus |
