Small-cell carcinoma of the gastrointestinal tract: A retrospective study of 64 cases Journal Article
| Authors: | Brenner, B.; Shah, M. A.; Gonen, M.; Klimstra, D. S.; Shia, J.; Kelsen, D. P. |
| Article Title: | Small-cell carcinoma of the gastrointestinal tract: A retrospective study of 64 cases |
| Abstract: | Small-cell carcinoma (SmCC) of the gastrointestinal tract is a very rare and aggressive malignancy. To better define its clinicopathological features, the records of all patients with this disease seen at Memorial Sloan Kettering Cancer Center between 1980 and 2002 (n = 64) were reviewed. The most common primary tumour locations were in the large bowel and oesophagus. Predisposing medical conditions for non-small-cell cancers, positive family cancer history, and metachronous tumours were common. In all, 37% had mixed tumour histology and 48% presented with extensive disease, according to the Veterans' Administration Lung Study group (VALSG) staging system used for small-cell lung cancer. Treatment outcome in limited disease (LD) suggested a role for surgery and chemotherapy. Platinum-based regimens resulted in a 50% response rate. The 2-year survival was 23% and two prognostic factors were identified, the extent of disease according to the VALSG system (P<0.01) and TNM stage (P = 0.03). Anatomic location had no clinical impact. In conclusion, SmCC from various gastrointestinal sites can be viewed as one clinical entity. Mixed tumour histology is common and may affect therapy. Surgery, combined with chemotherapy, should be considered for LD. The value of the VALSG system was implied and possible differences from small-cell lung cancer were noted. © 2004 Cancer Research UK. |
| Keywords: | adult; cancer chemotherapy; treatment outcome; aged; aged, 80 and over; middle aged; survival analysis; cancer surgery; retrospective studies; clinical feature; cancer staging; tumor localization; retrospective study; cancer therapy; histology; gastrointestinal neoplasms; disease progression; medical record; neoplasm metastasis; esophagus carcinoma; small cell carcinoma; carcinoma, small cell; small-cell carcinoma; gastrointestinal carcinoma; large intestine cancer; humans; prognosis; human; male; female; priority journal; article; the gastrointestinal tract |
| Journal Title: | British Journal of Cancer |
| Volume: | 90 |
| Issue: | 9 |
| ISSN: | 0007-0920 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-04-13 |
| Start Page: | 1720 |
| End Page: | 1726 |
| Language: | English |
| PROVIDER: | scopus |
| PMCID: | PMC2409752 |
| PUBMED: | 15150595 |
| DOI: | 10.1038/sj.bjc.6601758 |
| DOI/URL: | |
| Notes: | Br. J. Cancer -- Cited By (since 1996):54 -- Export Date: 16 June 2014 -- CODEN: BJCAA C2 - 15150595 -- Source: Scopus |
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