Quantitation of respiratory motion during 4D-PET/CT acquisition Journal Article


Authors: Nehmeh, S. A.; Erdi, Y. E.; Pan, T.; Yorke, E.; Mageras, G. S.; Rosenzweig, K. E.; Schoder, H.; Mostafavi, H.; Squire, O.; Pevsner, A.; Larson, S. M.; Humm, J. L.
Article Title: Quantitation of respiratory motion during 4D-PET/CT acquisition
Abstract: We report on the variability of the respiratory motion during 4D-PET/CT acquisition. The respiratory motion for five lung cancer patients was monitored by tracking external markers placed on the abdomen. CT data were acquired over an entire respiratory cycle at each couch position. The x-ray tube status was recorded by the tracking system, for retrospective sorting of the CT data as a function of respiration phase. Each respiratory cycle was sampled in ten equal bins. 4D-PET data were acquired in gated mode, where each breathing cycle was divided into ten 500 ms bins. For both CT and PET acquisition, patients received audio prompting to regularize breathing. The 4D-CT and 4D-PET data were then correlated according to their respiratory phases. The respiratory periods, and average amplitude within each phase bin, acquired in both modality sessions were then analyzed. The average respiratory motion period during 4D-CT was within 18% from that in the 4D-PET sessions. This would reflect up to 1.8% fluctuation in the duration of each 4D-CT bin. This small uncertainty enabled good correlation between CT and PET data, on a phase-to-phase basis. Comparison of the average-amplitude within the respiration trace, between 4D-CT and 4D- PET, on a bin-by-bin basis show a maximum deviation of ∼15%. This study has proved the feasibility of performing 4D-PET/CT acquisition. Respiratory motion was in most cases consistent between PET and CT sessions, thereby improving both the attenuation correction of PET images, and coregistration of PET and CT images. On the other hand, in two patients, there was an increased partial irregularity in their breathing motion, which would prevent accurately correlating the corresponding PET and CT images. © 2004 American Association of Physicists in Medicine.
Keywords: clinical article; treatment planning; cancer radiotherapy; positron emission tomography; computer assisted tomography; lung neoplasms; lung cancer; tomography, x-ray computed; imaging system; drug uptake; fluorodeoxyglucose f 18; positron-emission tomography; patient positioning; motion; artifact reduction; respiratory mechanics; breathing pattern; x ray; biophysics; thorax; movement; respiratory motion; four dimensional imaging; humans; human; priority journal; article; 4d-pet/ct
Journal Title: Medical Physics
Volume: 31
Issue: 6
ISSN: 0094-2405
Publisher: American Association of Physicists in Medicine  
Date Published: 2004-06-01
Start Page: 1333
End Page: 1338
Language: English
DOI: 10.1118/1.1739671
PROVIDER: scopus
PUBMED: 15259636
DOI/URL:
Notes: Med. Phys. -- Cited By (since 1996):128 -- Export Date: 16 June 2014 -- CODEN: MPHYA -- Source: Scopus
Altmetric Score
MSK Authors
  1. Alexander Pevsner
    12 Pevsner
  2. Heiko Schoder
    302 Schoder
  3. Gikas S Mageras
    264 Mageras
  4. Ellen D Yorke
    321 Yorke
  5. Sadek Nehmeh
    67 Nehmeh
  6. John Laurence Humm
    348 Humm
  7. Yusuf E Erdi
    109 Erdi
  8. Steven M Larson
    810 Larson
  9. Olivia D Squire
    32 Squire