Granulocyte-macrophage colony stimulating factor: An adjuvant for cancer vaccines Journal Article


Authors: Chang, D. Z.; Lomazow, W.; Somberg, C. J.; Stan, R.; Perales, M. A.
Article Title: Granulocyte-macrophage colony stimulating factor: An adjuvant for cancer vaccines
Abstract: Granulocyte-macrophage colony stimulating factor (GM-CSF) enhances immune responses by inducing the proliferation, maturation, and migration of dendritic cells, and the expansion and differentiation of B and T lymphocytes. There is significant data in pre-clinical animal models demonstrating the adjuvant effects of GM-CSF in a variety of cancer vaccine approaches, including cellular vaccines, viral vaccines, peptide and protein vaccines, and DNA vaccines. GM-CSF is an attractive vaccine adjuvant because of its immune modulation effects and low toxicity profile. The results in animal models have been confirmed in pilot clinical trials and several clinical trials are currently ongoing. © 2004 Taylor & Francis Ltd.
Keywords: unclassified drug; clinical trial; dose response; nonhuman; neoplasms; cell proliferation; glycoprotein gp 100; interleukin 2; melanoma; cell maturation; dendritic cell; carcinoembryonic antigen; epidermal growth factor receptor 2; granulocyte macrophage colony stimulating factor; pruritus; cancer vaccine; cancer vaccines; gene therapy; beta galactosidase; cell migration; dna vaccine; immunostimulation; monophenol monooxygenase; peptide vaccine; tumor; disease models, animal; tumor vaccine; adjuvants, immunologic; vaccines, dna; lymphadenopathy; recombinant granulocyte macrophage colony stimulating factor; t lymphocyte activation; clinical trials; vaccine; viral vaccines; recombinant vaccine; b lymphocyte differentiation; qs 21; adjuvant; granulocyte-macrophage colony-stimulating factor; freund adjuvant; granulocyte-macrophage colony stimulating factor; virus vaccine; b lymphocyte activation; humans; human; priority journal; article; cellular vaccine; aluminum potassium sulfate; protein vaccine
Journal Title: Hematology
Volume: 9
Issue: 3
ISSN: 1024-5332
Publisher: Maney Publishing  
Date Published: 2004-06-01
Start Page: 207
End Page: 215
Language: English
PROVIDER: scopus
PUBMED: 15204102
DOI: 10.1080/10245330410001701549
DOI/URL:
Notes: Hematology -- Cited By (since 1996):50 -- Export Date: 16 June 2014 -- CODEN: HMATF C2 - 15204102 -- Source: Scopus
Altmetric Score
MSK Authors
  1. David Chang
    5 Chang
  2. Miguel-Angel Perales
    363 Perales
  3. Rodica Stan
    10 Stan