Increased progesterone receptor expression in benign epithelium of BRCA1-related breast cancers Journal Article

  

Authors:	King, T. A.; Gemignani, M. L.; Li, W.; Giri, D. D.; Panageas, K. S.; Bogomolniy, F.; Arroyo, C.; Olvera, N.; Robson, M. E.; Offit, K.; Borgen, P. I.; Boyd, J.
Article Title:	Increased progesterone receptor expression in benign epithelium of BRCA1-related breast cancers
Abstract:	The study of pathologically normal breast epithelium of BRCA mutation carriers may yield insights into the early natural history of breast tumorigenesis. Hormone receptor expression was assessed in 24 cases of invasive breast cancer associated with a mutation in BRCA1 (n = 15) or BRCA2 (n = 9) and in 39 sporadic cases matched for patient age and tumor hormone receptor status. Expression of progesterone receptor was significantly (P = 0.0003) more common in normal breast epithelium adjacent to invasive breast carcinoma in BRCA7-linked cases compared with sporadic cases. The wild-type BRCA allele was retained in normal epithelium of all cases tested. We conclude that deregulation of progesterone receptor expression, as a result of BRCA1 haploinsufficiency, may represent an early event in BACA1-linked breast tumorigenesis.
Keywords:	adult; clinical article; controlled study; human tissue; protein expression; aged; middle aged; gene mutation; human cell; mutation; cancer risk; pathophysiology; breast cancer; genetic association; breast neoplasms; brca1 protein; brca2 protein; heterozygote; haplotype; cancer invasion; gene expression regulation; immunoenzyme techniques; oncogene; statistical significance; disease progression; breast epithelium; epithelial cells; receptors, progesterone; neoplasm invasiveness; age distribution; progesterone receptor; breast carcinogenesis; genetic linkage; carcinoma, ductal, breast; carcinoma, lobular; hormone receptor interaction; hormonal carcinogenesis; humans; human; female; priority journal; article
Journal Title:	Cancer Research
Volume:	64
Issue:	15
ISSN:	0008-5472
Publisher:	American Association for Cancer Research
Date Published:	2004-08-01
Start Page:	5051
End Page:	5053
Language:	English
DOI:	10.1158/0008-5472.can-04-1283
PROVIDER:	scopus
PUBMED:	15289302
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-3442883614&partnerID=40&md5=08b0f44b68b69c704029f70aca2f39db
Notes:	Cancer Res. -- Cited By (since 1996):21 -- Export Date: 16 June 2014 -- CODEN: CNREA -- Source: Scopus

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