Treatment of menorrhagia in women undergoing hematopoietic stem cell transplantation Journal Article

  


Authors: Amsterdam, A.; Jakubowski, A.; Castro-Malaspina, H.; Baxi, E.; Kauff, N.; Krychman, M.; Stier, E.; Castiel, M.
Article Title: Treatment of menorrhagia in women undergoing hematopoietic stem cell transplantation
Abstract: The management of uterine bleeding in female transplant patients over a 3-year period at our institution was reviewed. A total of 33 females who had undergone allogeneic hematopoietic stem cell transplant were identified as having received gynecologic consultation for the diagnosis of menorrhagia. Hormone therapy achieved a resolution of symptoms in 32 (97%) of the patients, and 26 (79%) required only one hormone regimen. Following resolution of symptoms, transition to standard-dose oral contraceptive pills as maintenance therapy prevented recurrent menorrhagia due to high circulating estrogen levels. Alternatives for patients who are unable to tolerate oral administration and those with hepatotoxicity are also discussed. © 2004 Nature Publishing Group All rights reserved.
Keywords: adolescent; adult; clinical article; controlled study; middle aged; retrospective studies; treatment; cytarabine; drug megadose; liver toxicity; estrogen; maintenance therapy; cyclophosphamide; stem cell transplantation; leuprorelin; estrogen replacement therapy; recurrent disease; allogeneic hematopoietic stem cell transplantation; hormonal therapy; gonadorelin agonist; oral contraceptive agent; medroxyprogesterone acetate; medical records; transplant; progesterone; medroxyprogesterone; menorrhagia; uterus bleeding; conjugated estrogen plus medroxyprogesterone acetate; ethinylestradiol; humans; human; female; priority journal; article
Journal Title: Bone Marrow Transplantation
Volume: 34
Issue: 4
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2004-08-01
Start Page: 363
End Page: 366
Language: English
DOI: 10.1038/sj.bmt.1704577
PROVIDER: scopus
PUBMED: 15195079
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-4444309022&partnerID=40&md5=205f9ebd11569eaf10bf1740701a6863
Notes: Bone Marrow Transplant. -- Cited By (since 1996):14 -- Export Date: 16 June 2014 -- CODEN: BMTRE -- Source: Scopus
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MSK Authors
  1. Alison Debora Amsterdam
    19 Amsterdam
  2. Michael Krychman
    19 Krychman
  3. Mercedes Castiel
    18 Castiel
  4. Noah Kauff
    128 Kauff
  5. Elizabeth A Stier
    12 Stier
  6. Ann Jakubowski
    459 Jakubowski
  7. Hugo Castro-Malaspina
    333 Castro-Malaspina
  8. Ekta Baxi
    1 Baxi
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