Cytokeratin positivity in paraffin-embedded malignant melanomas: Comparative study of KL1, A4 and Lu5 antibodies Journal Article
| Authors: | Korabiowska, M.; Fischer, G.; Steinacker, A.; Stachura, J.; Cordon-Cardo, C.; Brinck, U. |
| Article Title: | Cytokeratin positivity in paraffin-embedded malignant melanomas: Comparative study of KL1, A4 and Lu5 antibodies |
| Abstract: | The unclear role of cytokeratin (CK) in the progression and diagnostics of malignant melanomas stimulated us to compare the reactivity of three antibodies directed to CK in 109 paraffin-embedded melanomas. By far the majority of melanomas did not express cytokeratin even at the <1% level, only vimentin. In about 6% of melanomas it was possible to find CK expression ranging between 3 and 40% of melanoma cells. There was a correlation between CK expression and pT-stage. Cytokeratin-expressing tumours were found in the more advanced pT-stages. The independent prognostic values of none of the three CK antibodies investigated could be shown. |
| Keywords: | immunohistochemistry; adult; controlled study; human tissue; protein expression; aged; aged, 80 and over; middle aged; unclassified drug; cancer growth; cancer staging; cancer diagnosis; neoplasm staging; melanoma; antibodies, monoclonal; antibody specificity; malignant melanoma; cytokeratin 7; cytokeratin 19; cytokeratin; cytokeratin 14; cytokeratin 5; cytokeratin 6; keratins; antibody; immunoglobulin g1 antibody; paraffin; cytokeratin 18; cytokeratin 8; vimentin; paraffin embedding; cytokeratin 1; cytokeratin 10; cytokeratin 17; humans; prognosis; human; male; female; priority journal; article; a4 antibody; cytokeratin 11; cytokeratin 16; cytokeratin 2; kl1 antibody; lu5 antibody |
| Journal Title: | Anticancer Research |
| Volume: | 24 |
| Issue: | 5 B |
| ISSN: | 0250-7005 |
| Publisher: | International Institute of Anticancer Research |
| Date Published: | 2004-09-01 |
| Start Page: | 3203 |
| End Page: | 3207 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15510611 |
| DOI/URL: | |
| Notes: | Anticancer Res. -- Cited By (since 1996):9 -- Export Date: 16 June 2014 -- CODEN: ANTRD C2 - 15510611 -- Source: Scopus |
