No major association between TGFBR1*6A and prostate cancer Journal Article
| Authors: | Kaklamani, V.; Baddi, L.; Rosman, D.; Liu, J.; Ellis, N.; Oddoux, C.; Ostrer, H.; Chen, Y.; Ahsan, H.; Offit, K.; Pasche, B. |
| Article Title: | No major association between TGFBR1*6A and prostate cancer |
| Abstract: | Prostate cancer is the most commonly diagnosed cancer in men and one of the leading causes of cancer deaths. There is strong genetic evidence indicating that a large proportion of prostate cancers are caused by heritable factors but the search for prostate cancer susceptibility genes has thus far remained elusive. TGFBR1*6A, a common hypomorphic variant of the type I Transforming Growth Factor Beta receptor, is emerging as a tumor susceptibility allele that predisposes to the development of breast, colon and ovarian cancer. The association with prostate cancer has not yet been explored. A total of 907 cases and controls from New York City were genotyped to test the hypothesis that TGFBR1*6A may contribute to the development of prostate cancer. TGFBR1*6A allelic frequency among cases (0.086) was slightly higher than among controls (0.080) but the differences in TGFBR1*6A genotype distribution between cases and controls did not reach statistical significance (p = 0.67). Our data suggest that TGFBR1*6A does not contribute to the development of prostate cancer. © 2004 Kaklamani et al; licensee BioMed Central Ltd. |
| Keywords: | adult; controlled study; aged; aged, 80 and over; middle aged; unclassified drug; human cell; major clinical study; genetics; united states; allele; genetic predisposition to disease; genetic association; genotype; alleles; gene frequency; protein serine threonine kinase; prostate cancer; prostatic neoplasms; statistical significance; protein-serine-threonine kinases; prostate tumor; data analysis; transforming growth factor beta receptor; receptors, transforming growth factor beta; genetic predisposition; city; activin receptors, type i; humans; human; male; article; transforming growth factor beta receptor 1 6a; activin receptor 1; tgf beta type i receptor; tgf-beta type i receptor |
| Journal Title: | BMC Genetics |
| Volume: | 5 |
| ISSN: | 1471-2156 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2004-09-22 |
| Language: | English |
| DOI: | 10.1186/1471-2156-5-28 |
| PROVIDER: | scopus |
| PMCID: | PMC521683 |
| PUBMED: | 15385056 |
| DOI/URL: | |
| Notes: | BMC Genet. -- Cited By (since 1996):11 -- Export Date: 16 June 2014 -- CODEN: BGMED -- Source: Scopus |
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