Abstract: |
Two novel (bifunctional) chelating agents, TAME-Hex A and B, which are polyaminopolycarboxylic acids based on the tripodal TAME [tris(aminomethyl) ethane] structure, have been designed and synthesized. The chelators show very good stability with gallium(III) ions and thus are highly effective candidates for use in radioimmunoimaging (RII), especially in positron emission tomography (PET). © Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004. |
Keywords: |
unclassified drug; positron emission tomography; imaging; chelate; polymer; synthesis; chelating agents; carboxylic acid derivative; molecular stability; gallium; chelating agent; radioimmunoimaging; new drug; article; gallium chelate; tame derivative; ethane; polyaminocarboxylic acid derivative; tris(aminomethyl)ethane; tris(aminomethyl)ethane n,n,n',n',n',n'' hexaacetic acid
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