Donor activating KIR3DS1 is associated with decreased acute GVHD in unrelated allogeneic hematopoietic stem cell transplantation Journal Article
| Authors: | Venstrom, J. M.; Gooley, T. A.; Spellman, S.; Pring, J.; Malkki, M.; Dupont, B.; Petersdorf, E.; Hsu, K. C. |
| Article Title: | Donor activating KIR3DS1 is associated with decreased acute GVHD in unrelated allogeneic hematopoietic stem cell transplantation |
| Abstract: | The natural killer cell receptor KIR3DS1 is associated with improved outcome in malignancies, infections, and autoimmune diseases, but data for the impact of KIR3DS1 in HSCT are inconsistent. Using genomic DNA from the National Marrow Donor Program, we performed donor KIR genotyping for 1087 patients who received an unrelated hematopoietic stem cell transplantation. A total of 33% of donors were KIR3DS1+. Compared with KIR3DS1- donors, donor KIR3DS1 was associated with lower-grade II-IV acute graft-versus-host disease (GVHD; odds ratio = 0.71; 95% confidence interval, 0.55-0.92; P = .009), but not with relapse (hazard ratio = 0.97; 95% confidence interval, 0.73-1.29; P = .82). Furthermore, grade II-IV acute GVHD, overall mortality, and transplantation-related mortality all decreased as the number of copies of donor KIR3DS1 increased (P = .007, P = .03, and P = .02, respectively), with the lowest failure rate occurring among patients homozygous for donor KIR3DS1. Selection of donors with KIR3DS1 may decrease acute GVHD without compromising relapse-free survival, separating the graft-versus-tumor effect from unwanted GVHD. © 2010 by The American Society of Hematology. |
| Keywords: | adolescent; adult; child; controlled study; preschool child; school child; treatment outcome; aged; child, preschool; middle aged; transplantation, homologous; young adult; acute granulocytic leukemia; major clinical study; mortality; genetic association; genotype; hematopoietic stem cell transplantation; chronic myeloid leukemia; acute lymphoblastic leukemia; homozygosity; acute graft versus host disease; myelodysplastic syndrome; donor; tissue donors; infant; heterozygosity; graft versus host reaction; allogeneic hematopoietic stem cell transplantation; cyclosporin a; hla b antigen; graft vs host disease; acute disease; killer cell immunoglobulin like receptor 3ds1; receptors, kir3ds1 |
| Journal Title: | Blood |
| Volume: | 115 |
| Issue: | 15 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2010-04-15 |
| Start Page: | 3162 |
| End Page: | 3165 |
| Language: | English |
| DOI: | 10.1182/blood-2009-08-236943 |
| PUBMED: | 20124216 |
| PROVIDER: | scopus |
| PMCID: | PMC2858471 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 20 April 2011" - "CODEN: BLOOA" - "Source: Scopus" |
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