Total synthesis of (±)-jiadifenin, a non-peptidyl neurotrophic modulator Journal Article
| Authors: | Cho, Y. S.; Carcache, D. A.; Tian, Y.; Li, Y. M.; Danishefsky, S. J. |
| Article Title: | Total synthesis of (±)-jiadifenin, a non-peptidyl neurotrophic modulator |
| Abstract: | We report the first total synthesis of jiadifenin (1), the establishment of a modality for its biological evaluation, and the discovery of apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1. Copyright © 2004 American Chemical Society. |
| Keywords: | controlled study; unclassified drug; methylation; nonhuman; reproducibility; animal cell; animal; animals; nerve growth factors; drug structure; drug effect; drug synthesis; rat; thermodynamics; rats; cyclization; structure analysis; x ray crystallography; oxidation; technique; acetal derivative; synthesis; drug isolation; ring closing metathesis; stereochemistry; sesquiterpenes; sesquiterpene; diastereoisomer; bromination; reduction; neurotrophic factor; deprotection reaction; cell strain; ketone derivative; brain cell; nerve fiber growth; nerve growth factor; pc12 cells; jiadifenin; illicium; illicium jiadifengpi; neurite; neurites; article; 1,4 cyclohexanedione ethylene ketal; cyclohexanone derivative; hydroxy 3,4 dehydroneomanjucin; sesquiterpene derivative; horner wadsworth emmons reaction |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 126 |
| Issue: | 44 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2004-11-10 |
| Start Page: | 14358 |
| End Page: | 14359 |
| Language: | English |
| DOI: | 10.1021/ja045939p |
| PROVIDER: | scopus |
| PUBMED: | 15521747 |
| DOI/URL: | |
| Notes: | J. Am. Chem. Soc. -- Cited By (since 1996):33 -- Export Date: 16 June 2014 -- CODEN: JACSA -- Source: Scopus |
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3Carcache -
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Cho -
539Danishefsky -
132Li -
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Tian
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