Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas Journal Article

  

Authors:	Sarkaria, I. S.; Stojadinovic, A.; Talbot, S. G.; Hoos, A.; Dudas, M. E.; Brennan, M. F.; Ghossein, R. A.; Singh, B.
Article Title:	Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas
Abstract:	Our previous work has demonstrated squamous cell carcinoma-related oncogene (SCCRO) expression in adult murine adrenocortical tissue. The aim of this study was to assess patterns of SCCRO expression in the embryonic murine adrenal gland, and in normal and neoplastic human adrenocortical tissues in order to determine its role as a marker of differentiation in adrenocortical development and neoplastic progression. Murine embryos were procured at developmental stages E8 to E18. A tissue microarray was constructed containing 38 normal, 39 adenomatous, and 87 carcinomatous human adrenocortical specimens. Immunohistochemistry for SCCRO was performed and its expression was graded in suitable tissues. SCCRO expression was detected in the murine adrenal cortex as early as E15 and persisted into the postnatal period. High-level SCCRO expression was identified in 94% of normal (32/34) and adenomatous (29/31) adrenocortical specimens but in only 63% (45/72) of adrenocortical carcinoma (ACC) specimens (P =. 001). Loss of SCCRO expression in primary ACC (13/34 (34%)) correlated with advanced stage (P =. 06), presence of M1 disease at presentation (P =. 03), and worse overall survival (P =. 006). SCCRO appears to be a marker of adrenocortical differentiation in both murine and human systems. SCCRO expression may be useful in distinguishing adrenocortical adenomas from ACC. Moreover, loss of SCCRO expression in primary ACC is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors.
Keywords:	immunohistochemistry; clinical article; controlled study; survival analysis; survival rate; carcinoma, squamous cell; nonhuman; biological markers; mouse; animals; mice; animal tissue; gene expression; embryo; serpins; cell transformation, neoplastic; oncogenes; adrenal cortex carcinoma; oncogene; correlation analysis; antigens, neoplasm; outcomes research; dna microarray; developmental stage; marker gene; adrenocortical carcinoma; adrenal cortex neoplasms; squamous cell carcinoma related oncogene; adrenal glands; adrenocortical adenoma; humans; prognosis; human; male; female; priority journal; article
Journal Title:	Surgery
Volume:	136
Issue:	6
ISSN:	0039-6060
Publisher:	Elsevier Inc.
Date Published:	2004-12-01
Start Page:	1122
End Page:	1128
Language:	English
DOI:	10.1016/j.surg.2004.06.041
PROVIDER:	scopus
PUBMED:	15657565
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-10644295474&partnerID=40&md5=79a980c8eea6675ee87720f74810949a
Notes:	Surgery -- Cited By (since 1996):5 -- Export Date: 16 June 2014 -- CODEN: SURGA -- Source: Scopus

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