A prospective analysis of the effect of blue-dye volume on sentinel lymph node mapping success and incidence of allergic reaction in patients with breast cancer Journal Article
| Authors: | King, T. A.; Fey, J. V.; Van Zee, K. J.; Heerdt, A. S.; Gemignani, M. L.; Port, E. R.; Sclafani, L.; Sacchini, V.; Petrek, J. A.; Cody, H. S. 3rd; Borgen, P. I.; Montgomery, L. L. |
| Article Title: | A prospective analysis of the effect of blue-dye volume on sentinel lymph node mapping success and incidence of allergic reaction in patients with breast cancer |
| Abstract: | Background: This study examined whether the volume of isosulfan blue dye used in sentinel lymph node (SLN) mapping in breast cancer is related to the SLN identification rate or to the incidence of allergic reactions. Methods: From January 2001 to November 2002, 1728 breast cancer patients underwent 1832 SLN mapping procedures with the combined technique of intraparenchymal blue dye and intradermal radioisotope. Details of each procedure and all allergic reactions were prospectively recorded. Bilateral synchronous SLN procedures were considered as one dye exposure but as two distinct procedures for determining mapping success. Dye-only success was defined as the proportion of cases in which the SLN was identified by blue dye alone. Overall dye success was defined as the proportion of cases in which the SLN was identified by blue dye with or without isotope. Results: When stratified by volume of blue dye, there were no significant differences in dye-only successes, overall dye successes, or mapping failures. Allergic reactions were documented in 31 (1.8%) of 1728 patients. Hypotensive reactions occurred in 3 (.2%) of 1728 patients; 2 (.1%) required pressor support. There was a nonsignificant trend toward fewer allergic reactions with smaller volumes of blue dye. Conclusions: In combined-technique SLN mapping protocols for breast cancer, using smaller volumes of blue dye may represent a means of optimizing the safety of the procedure without compromising its success. © 2004 The Society of Surgical Oncology, Inc. |
| Keywords: | adult; controlled study; aged; aged, 80 and over; middle aged; major clinical study; clinical trial; side effect; methodology; isosulfan blue; prospective study; sentinel lymph node; prospective studies; rosaniline dyes; sentinel lymph node biopsy; diagnostic procedure; breast cancer; risk factors; pathology; breast neoplasms; risk factor; risk assessment; drug hypersensitivity; pruritus; rash; hypotension; statistical significance; diagnostic agent; chemically induced disorder; breast tumor; radioisotope; corticosteroid; allergic reaction; urticaria; hypertensive factor; diphenhydramine; ephedrine; humans; human; female; article; allergic reactions; isosulfan blue dye; fuchsine; iso sulfan blue; iso-sulfan blue |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 11 |
| Issue: | 5 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2004-05-01 |
| Start Page: | 535 |
| End Page: | 541 |
| Language: | English |
| DOI: | 10.1245/aso.2004.10.014 |
| PROVIDER: | scopus |
| PUBMED: | 15123464 |
| DOI/URL: | |
| Notes: | Ann. Surg. Oncol. -- Cited By (since 1996):39 -- Export Date: 16 June 2014 -- CODEN: ASONF -- Source: Scopus |
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