Surgical resection and high dose rate intraoperative radiation therapy for locally recurrent rectal cancer Journal Article

  


Authors: Idrees, K.; Minsky, B.; Alektiar, K.; Guillem, J.; Weiser, M.; Temple, L.; Wong, W. D.; Paty, P.
Article Title: Surgical resection and high dose rate intraoperative radiation therapy for locally recurrent rectal cancer
Abstract: For intra-pelvic recurrence of rectal cancer, surgical resection is technically difficult and must be aggressive to achieve a high rate of negative resection margins. Resection with clear margins can be curative, particularly for those patients with true anastomotic recurrence. HDR-IORT is a safe, feasible, versatile, logistically sound modality that is highly reliable in delivering radiation to at-risk surgical margins in the pelvis. Despite surgery and IORT, overall local failure rates in this population are 33 to 50 percent. The most important prognostic variable is the state of surgical resection margins. At our institution, in patients with negative and positive resection margins the 2-year actuarial local recurrence rates are 33 percent versus 73 percent and 5-year survival rates are 51 percent versus 16 percent, respectively. On subset analysis, the most favorable outcome was seen in patients with true anastomotic recurrences (78 percent 5-year survival).
Keywords: disease-free survival; middle aged; survival rate; mortality; multimodality cancer therapy; disease free survival; radiation dose; combined modality therapy; metastasis; neoplasm recurrence, local; radiotherapy dosage; pathology; intraoperative period; tumor recurrence; pelvis tumor; pelvic neoplasms; rectal neoplasms; rectum tumor; humans; human; male; female; article
Journal Title: Acta Chirurgica Iugoslavica
Volume: 51
Issue: 3
ISSN: 0354-950X
Publisher: Clinical Center of Serbia  
Date Published: 2004-01-01
Start Page: 11
End Page: 18
Language: English
PROVIDER: scopus
DOI: 10.2298/ACI0403011I
PUBMED: 16018360
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33644623146&partnerID=40&md5=b33f5bd991a24cbf46cedd204088f7ef
Notes: Cited By (since 1996):2 -- Export Date: 16 June 2014 -- Source: Scopus
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MSK Authors
  1. Kamran Idrees
    10 Idrees
  2. Philip B Paty
    499 Paty
  3. Bruce Minsky
    306 Minsky
  4. Kaled M Alektiar
    333 Alektiar
  5. Jose Guillem
    414 Guillem
  6. Martin R Weiser
    538 Weiser
  7. Larissa Temple
    193 Temple
  8. Douglas W Wong
    178 Wong
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