Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer Journal Article
| Authors: | Hawkins, W. G.; DeMatteo, R. P.; Jarnagin, W. R.; Ben-Porat, L.; Blumgart, L. H.; Fong, Y. |
| Article Title: | Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer |
| Abstract: | Background: In patients with gallbladder cancer, jaundice suggests tumor involvement of the porta hepatis. This study reports on the prevalence, etiology, and clinical significance of jaundice in patients with gallbladder cancer. Methods: Patients who presented with gallbladder cancer from 1995 to 2002 were entered into a prospective database. Disease-specific survival and clinicopathologic correlates were analyzed. Results: Eighty-two (34%) of 240 patients with gallbladder cancer presented with jaundice. Jaundiced patients (96%) were more likely (P < .001) to have advanced-stage disease than nonjaundiced patients (60%). Only six (7%) jaundiced patients were resected with curative intent, and only four (5%) had negative surgical margins. This was significantly different from the nonjaundiced group, in which 62 patients (39%) had negative margins (P < .001). The median disease-specific survival in patients presenting with jaundice was 6 months and was significantly lower compared with 16 months in patients without jaundice (P < .0001). In the group presenting with jaundice, there were no disease-free survivors at 2 years, compared with 21% in the group without jaundice. Conclusions: Jaundice is common (34%) in patients who present with gallbladder cancer and is an indicator of advanced malignancy. These data do not support routine operative exploration of patients with jaundice secondary to gallbladder cancer. © 2004 The Society of Surgical Oncology, Inc. |
| Keywords: | survival; adult; cancer survival; controlled study; treatment outcome; aged; middle aged; survival analysis; cancer surgery; major clinical study; advanced cancer; cancer staging; neoplasm staging; prospective study; prospective studies; prevalence; risk factors; pathology; data base; prediction; risk factor; cancer mortality; correlation analysis; jaundice; cholecystectomy; gallbladder neoplasms; factual database; databases, factual; gallbladder cancer; gallbladder tumor; gallbladder; cancer; humans; prognosis; human; male; female; article; operative exploration |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 11 |
| Issue: | 3 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2004-03-01 |
| Start Page: | 310 |
| End Page: | 315 |
| Language: | English |
| DOI: | 10.1245/aso.2004.03.011 |
| PROVIDER: | scopus |
| PUBMED: | 14993027 |
| DOI/URL: | |
| Notes: | Ann. Surg. Oncol. -- Cited By (since 1996):63 -- Export Date: 16 June 2014 -- CODEN: ASONF -- Source: Scopus |
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