Semi-artificial fluorescent molecular machine for DNA damage detection Journal Article
| Authors: | Didenko, V. V.; Minchew, C. L.; Shuman, S.; Baskin, D. S. |
| Article Title: | Semi-artificial fluorescent molecular machine for DNA damage detection |
| Abstract: | The design of artificial molecular machines is complicated because the mechanics used in macromachines is not readily adaptable for nano environments. We constructed a semi-artificial molecular device, which contains a naturally occurring molecular machine-a vaccinia virus encoded protein-linked with an artificial part. The self-assembled construct makes two fluorescently labeled detector units. It is the first sensor capable of selectively detecting different types of DNA breaks, exemplifying a practical approach to the design of molecular devices. |
| Keywords: | fluorescence; dna; molecular biology; enzymes; chemical bonds; damage detection; micromachine designs; molecular machines; oligonuceotides; brownian movement; energy absorption; nanostructured materials |
| Journal Title: | Nano Letters |
| Volume: | 4 |
| Issue: | 12 |
| ISSN: | 1530-6984 |
| Publisher: | American Chemical Society |
| Date Published: | 2004-01-01 |
| Start Page: | 2461 |
| End Page: | 2466 |
| Language: | English |
| DOI: | 10.1021/nl048357e |
| PROVIDER: | scopus |
| PMCID: | PMC1805678 |
| PUBMED: | 17330146 |
| DOI/URL: | |
| Notes: | Nano Lett. -- Cited By (since 1996):6 -- Export Date: 16 June 2014 -- Source: Scopus |
