Adrenocortical carcinoma: The influence of large vessel extension Journal Article
| Authors: | Turbendian, H. K.; Strong, V. E.; Hsu, M.; Ghossein, R. A.; Fahey, T. J. 3rd |
| Article Title: | Adrenocortical carcinoma: The influence of large vessel extension |
| Abstract: | Background: The impact of large vessel extension (LVE) as a prognostic factor for adrenocortical carcinoma (ACC) is not fully understood. This study aimed to assess outcome of ACC in the presence and absence of LVE. Methods: A retrospective review of 57 patients undergoing curative intent resection for ACC over 10 years is presented comparing those with and without LVE. LVE was defined as vascular wall invasion or intraluminal extension of the neoplasm into the inferior vena cava or renal vein. Preoperative diagnostics, operative details, pathology, overall survival (OS), and recurrence-free survival (RFS) were analyzed. Results: Multivariable regression analysis showed a significant association for decreased survival with Stage III and IV disease and LVE. Patients with LVE had more functional neoplasms, greater preoperative serum hormone levels, and more positive margins than those without LVE. Median OS was 6 years and RFS 3 years. Kaplan-Meier analysis demonstrated a significant decrease in OS and RFS with LVE. Median OS with and without LVE was 18 vs 111 months and median RFS was 11 vs 64 months. Three-year OS with and without LVE were 29% vs 93% and 3 year RFS was 15% vs 67%. Conclusion: In addition to systemic and lymph node metastases, LVE is associated with poorer OS and RFS. © 2010 Mosby, Inc. All rights reserved. |
| Keywords: | adolescent; adult; cancer survival; aged; disease-free survival; middle aged; survival rate; retrospective studies; major clinical study; cancer recurrence; cancer staging; lymph nodes; neoplasm staging; time factors; adrenal cortex carcinoma; cancer invasion; preoperative period; neoplasm metastasis; neoplasm invasiveness; inferior cava vein; adrenal cortex neoplasms; kidney vein; renal veins; vena cava, inferior; hormone blood level |
| Journal Title: | Surgery |
| Volume: | 148 |
| Issue: | 6 |
| ISSN: | 0039-6060 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-12-01 |
| Start Page: | 1057 |
| End Page: | 1064 |
| Language: | English |
| DOI: | 10.1016/j.surg.2010.09.024 |
| PUBMED: | 21134533 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: SURGA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work