Evaluation of lymph node counts in primary retroperitoneal lymph node dissection Journal Article

Authors: Thompson, R. H.; Carver, B. S.; Bosl, G. J.; Bajorin, D.; Motzer, R.; Feldman, D.; Reuter, V. E.; Sheinfeld, J.
Article Title: Evaluation of lymph node counts in primary retroperitoneal lymph node dissection
Abstract: BACKGROUND: Lymph node counts are a measure of quality assurance and are associated with prognosis for numerous malignancies. To date, investigations of lymph node counts in testis cancer are lacking. METHODS: By using the Memorial Sloan-Kettering Testis Cancer database, the authors identified 255 patients who underwent primary retroperitoneal lymph node dissection (RPLND) for nonseminomatous germ cell tumors (NSGCTs) between 1999 and 2008. Features that were associated with lymph node counts, positive lymph nodes, the number of positive lymph nodes, and the risk of positive contralateral lymph nodes were evaluated with regression models. RESULTS: The median (interquartile range [IQR]) total lymph node count was 38 lymph nodes (IQR, 27-53 total lymph nodes), and it was 48 (IQR, 34-61 total lymph nodes) during the most recent 5 years. Features that were associated with higher lymph node count on multivariate analysis included high-volume surgeon (P =.034), clinical stage (P =.036), and more recent year of surgery (P <.001); whereas pathologist was not associated significantly with lymph node count (P =.3). Clinical stage (P <.001) and total lymph node count (P =.045) were associated significantly with finding positive lymph nodes on multivariate analysis. The probability of finding positive lymph nodes was 23%, 23%, 31%, and 48% if the total lymph node count was <21, 21 to 40, 41 to 60, and >60, respectively. With a median follow-up of 3 years, all patients remained alive, and 16 patients developed recurrent disease, although no patients developed recurrent disease in the paracaval, interaortocaval, para-aortic, or iliac regions. CONCLUSIONS: The current results suggested that >40 lymph nodes removed at RPLND improve the diagnostic efficacy of the operation. The authors believe that these results will be useful for future trials comparing RPLNDs, especially when assessing the adequacy of lymph node dissection. © 2010 American Cancer Society.
Keywords: adult; cancer survival; human tissue; major clinical study; cancer recurrence; cancer staging; lymph node dissection; paraaortic lymph node; lymph nodes; lymphatic metastasis; neoplasm staging; lymph node excision; neoplasms; testicular neoplasms; neoplasms, germ cell and embryonal; testis cancer; germ cell tumor; retroperitoneal space; testicular
Journal Title: Cancer
Volume: 116
Issue: 22
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2010-11-15
Start Page: 5243
End Page: 5250
Language: English
DOI: 10.1002/cncr.25266
PUBMED: 20665486
PROVIDER: scopus
PMCID: PMC4174298
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: CANCA" - "Source: Scopus"
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MSK Authors
  1. Dean Bajorin
    416 Bajorin
  2. Robert Motzer
    769 Motzer
  3. Darren Richard Feldman
    172 Feldman
  4. Joel Sheinfeld
    197 Sheinfeld
  5. Brett Stewart Carver
    109 Carver
  6. Victor Reuter
    922 Reuter
  7. George Bosl
    270 Bosl