Integrative genomic profiling of human prostate cancer Journal Article


Authors: Taylor, B. S.; Schultz, N.; Hieronymus, H.; Gopalan, A.; Xiao, Y.; Carver, B. S.; Arora, V. K.; Kaushik, P.; Cerami, E.; Reva, B.; Antipin, Y.; Mitsiades, N.; Landers, T.; Dolgalev, I.; Major, J. E.; Wilson, M.; Socci, N. D.; Lash, A. E.; Heguy, A.; Eastham, J. A.; Scher, H. I.; Reuter, V. E.; Scardino, P. T.; Sander, C.; Sawyers, C. L.; Gerald, W. L.
Article Title: Integrative genomic profiling of human prostate cancer
Abstract: Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in ∼11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource. © 2010 Elsevier Inc.
Keywords: signal transduction; adult; controlled study; human tissue; aged; aged, 80 and over; middle aged; primary tumor; unclassified drug; gene cluster; animals; mice; metastasis; microrna; gene expression profiling; nuclear protein; tumor markers, biological; relapse; transcription factor; tumor cells, cultured; prostate cancer; prostatic neoplasms; oligonucleotide array sequence analysis; prostatectomy; cancer cell; oncogene proteins, fusion; neoplasm metastasis; transplantation, heterologous; binding protein; androgen receptor; gene dosage; chromosome deletion; comparative genomic hybridization; chromosome 3p; genome, human; chromosomes, human, pair 3; protein shq; ring yy1 and binding protein; transcription factor foxp1
Journal Title: Cancer Cell
Volume: 18
Issue: 1
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2010-07-13
Start Page: 11
End Page: 22
Language: English
DOI: 10.1016/j.ccr.2010.05.026
PUBMED: 20579941
PROVIDER: scopus
PMCID: PMC3198787
DOI/URL:
Notes: --- - "Cited By (since 1996): 34" - "Export Date: 20 April 2011" - "CODEN: CCAEC" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Charles L Sawyers
    157 Sawyers
  2. Adriana Heguy
    85 Heguy
  3. Peter T Scardino
    621 Scardino
  4. William L Gerald
    370 Gerald
  5. Anuradha Gopalan
    275 Gopalan
  6. Vivek Kumar Arora
    10 Arora
  7. Yonghong Xiao
    6 Xiao
  8. James Eastham
    427 Eastham
  9. Boris A Reva
    36 Reva
  10. Brett Stewart Carver
    109 Carver
  11. Alex E Lash
    24 Lash
  12. Nicholas D Socci
    188 Socci
  13. Chris Sander
    196 Sander
  14. Victor Reuter
    921 Reuter
  15. Howard Scher
    834 Scher
  16. Barry Stephen Taylor
    144 Taylor
  17. Ethan Cerami
    21 Cerami
  18. Nikolaus D Schultz
    206 Schultz
  19. Yevgeniy Antipin
    19 Antipin
  20. John E Major
    6 Major
  21. Manda E Wilson
    5 Wilson