A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor Journal Article
| Authors: | Taldone, T.; Zatorska, D.; Kang, Y.; Chiosis, G. |
| Article Title: | A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor |
| Abstract: | PU-H71 is a purine-scaffold Hsp90 inhibitor currently undergoing late stage preclinical evaluation for the treatment of cancer. In this investigation, we present a simple method for the synthesis of d6-labeled PU-H71 for use as an internal standard to accurately quantitate the drug in biological matrices based on an LC-MS-MS method. PU-H71-d6 was synthesized in five steps using readily available 1,3-dibromopropane-d6 and is an important compound for the advancement of our clinical program. Copyright © 2009 John Wiley & Sons, Ltd. |
| Keywords: | unclassified drug; inhibitor; drug synthesis; isotope labeling; radiopharmaceutical agent; heat shock protein 90; tandem mass spectrometry; liquid chromatography; purine; deuterium labeled pu-h71; pu h 71; pu h71 d 6 |
| Journal Title: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume: | 53 |
| Issue: | 1 |
| ISSN: | 0362-4803 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-01-01 |
| Start Page: | 47 |
| End Page: | 49 |
| Language: | English |
| DOI: | 10.1002/jlcr.1689 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: JLCRD" - "Source: Scopus" |
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