Current treatment options for recurrent nasopharyngeal cancer Journal Article
| Authors: | Suárez, C.; Rodrigo, J. P.; Rinaldo, A.; Langendijk, J. A.; Shaha, A. R.; Ferlito, A. |
| Article Title: | Current treatment options for recurrent nasopharyngeal cancer |
| Abstract: | Loco-regional control rate of nasopharyngeal carcinoma (NPC) has improved significantly in the past decade. However, local recurrence still represents a major cause of mortality and morbidity in advanced stages, and management of local failure remains a challenging issue in NPC. The best salvage treatment for local recurrent NPC remains to be determined. The options include brachytherapy, external radiotherapy, stereotactic radiosurgery, and nasopharyngectomy, either alone or in different combinations. In this article we will discuss the different options for salvage of locally recurrent NPC. Retreatment of locally recurrent NPC using radiotherapy, alone or in combination with other treatment modalities, as well as surgery, can result in long-term local control and survival in a substantial proportion of patients. For small-volume recurrent tumors (T1-T2) treated with external radiotherapy, brachytherapy or stereotactic radiosurgery, comparable results to those obtained with surgery have been reported. In contrast, treatment results of advanced-stage locally recurrent NPC are generally more satisfactory with surgery (with or without postoperative radiotherapy) than with reirradiation. © 2010 The Author(s). |
| Keywords: | cancer survival; patient satisfaction; surgical technique; review; cancer recurrence; intensity modulated radiation therapy; cisplatin; radiation dose; neurotoxicity; nuclear magnetic resonance imaging; positron emission tomography; antineoplastic agent; metastasis; computer assisted tomography; radiotherapy; morbidity; cancer mortality; temporal lobe; fluorodeoxyglucose f 18; xerostomia; brachytherapy; stereotactic radiosurgery; external beam radiotherapy; nasopharynx cancer; nasopharyngeal carcinoma; endoscopy; epistaxis; brain necrosis; cranial nerve paralysis; brain hemorrhage; serology; trismus; bone necrosis; radiation necrosis; cranial neuropathy; brain edema; recurrent; nasopharyngectomy; middle ear effusion; mixed hearing loss |
| Journal Title: | European Archives of Oto-Rhino-Laryngology |
| Volume: | 267 |
| Issue: | 12 |
| ISSN: | 0937-4477 |
| Publisher: | Springer |
| Date Published: | 2010-12-01 |
| Start Page: | 1811 |
| End Page: | 1824 |
| Language: | English |
| DOI: | 10.1007/s00405-010-1385-x |
| PROVIDER: | scopus |
| PMCID: | PMC2966947 |
| PUBMED: | 20865269 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: EAOTE" - "Source: Scopus" |
