The effect of margin width on local recurrence of triple negative breast cancer Journal Article
| Authors: | Pilewskie, M.; Morrow, M. |
| Article Title: | The effect of margin width on local recurrence of triple negative breast cancer |
| Abstract: | Data addressing margin width and the risk of local recurrence (LR) for women undergoing breast-conserving therapy have not revealed improved recurrence rates with larger negative margins. However, incidence of LR has been revealed to vary between breast cancer subtypes, with the incidence of LR higher for triple negative (TN) breast cancer than for non-TN cancers, raising the question of whether the same margin width is appropriate for all breast cancer subtypes. This paper reviews the literature addressing margin status in breast-conserving therapy within the TN subtype. Current evidence does not support a wider surgical margin for TN breast cancer. Recent studies reveal similar LR for TN breast cancer treated with breast conservation and with mastectomy, suggesting that cancer biology, and not the negative margin width, determines the risk of LR. © Springer Science+Business Media 2014. |
| Keywords: | cancer survival; cancer surgery; excision; review; cancer recurrence; cancer combination chemotherapy; systemic therapy; methotrexate; recurrence risk; lymph node metastasis; mastectomy; cancer mortality; distant metastasis; high risk patient; minimal residual disease; breast carcinoma; cancer size; partial mastectomy; reoperation; tamoxifen; invasive carcinoma; cancer classification; trastuzumab; intraductal carcinoma; margins; regional metastasis; surgical margin; breast-conserving therapy; randomized controlled trial (topic); local recurrence; meta analysis (topic); triple negative breast cancer; tumor invasion; medical parameters; cancer prognosis; long term survival; human; cancer local recurrence |
| Journal Title: | Current Breast Cancer Reports |
| Volume: | 6 |
| Issue: | 1 |
| ISSN: | 1943-4588 |
| Publisher: | Springer |
| Date Published: | 2014-01-04 |
| Start Page: | 32 |
| End Page: | 37 |
| Language: | English |
| DOI: | 10.1007/s12609-013-0132-x |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Curr. Breast Cancer Rep. -- Export Date: 2 June 2014 -- Source: Scopus |
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