Anaplastic thyroid carcinoma: A 25-year single-institution experience Journal Article


Authors: Mohebati, A.; DiLorenzo, M.; Palmer, F.; Patel, S. G.; Pfister, D.; Lee, N.; Tuttle, R. M.; Shaha, A. R.; Shah, J. P.; Ganly, I.
Article Title: Anaplastic thyroid carcinoma: A 25-year single-institution experience
Abstract: Background: Anaplastic thyroid carcinoma (ATC) is among the most aggressive solid tumors accounting for 1-5 % of primary thyroid malignancies. In this retrospective review, we aim to evaluate the prognostic factors, treatment approaches, and outcomes of patients with ATC treated at a single institution. Materials and Methods: We retrospectively identified 95 patients with ATC from an institutional database between 1985 and 2010. A total of 83 patients with sufficient records were included in this study. Patient, tumor, and treatment characteristics were recorded. Disease-specific survival (DSS) was determined by the Kaplan-Meier method, and factors predictive of outcome were determined by univariate and multivariate analysis. Results: Of the 83 patients, 41 were male and 42 were female. The median age at presentation was 60 years (range 28-89 years) with a median survival of 8 months. The 1- and 2-year DSS were 33 and 23 %, respectively. On univariate analysis, age less than 60 years, clinically N0 neck, absence of clinical extrathyroidal extension (cETE), gross total resection, and multimodality treatment were statistically significant predictors of improved survival. On multivariate analysis, absence of cETE, multimodality therapy, and gross total resection were predictors of improved outcome. Conclusions: In patients with locoregional limited disease, multimodality treatment with gross total surgical resection and postoperative radiotherapy with or without chemotherapy offers the best local control and DSS. © 2014 Society of Surgical Oncology.
Keywords: adult; cancer chemotherapy; aged; cancer surgery; survival rate; major clinical study; overall survival; doxorubicin; cancer radiotherapy; outcome assessment; follow up; data base; retrospective study; disease severity; thyroidectomy; predictor variable; platinum; thyroid carcinoma; lobectomy; disease specific survival; predictive value; chemoradiotherapy; subtotal thyroidectomy; cancer prognosis; human; male; female; article
Journal Title: Annals of Surgical Oncology
Volume: 21
Issue: 5
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2014-05-01
Start Page: 1665
End Page: 1670
Language: English
DOI: 10.1245/s10434-014-3545-5
PROVIDER: scopus
PUBMED: 24554064
DOI/URL:
Notes: Ann. Surg. Oncol. -- Export Date: 2 June 2014 -- CODEN: ASONF -- Source: Scopus
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MSK Authors
  1. Ashok R Shaha
    700 Shaha
  2. Snehal G Patel
    417 Patel
  3. Robert M Tuttle
    484 Tuttle
  4. Nancy Y. Lee
    889 Lee
  5. David G Pfister
    389 Pfister
  6. Ian Ganly
    433 Ganly
  7. Jatin P Shah
    725 Shah
  8. Frank Palmer
    82 Palmer