Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies Journal Article
| Authors: | Davila, M. L.; Bouhassira, D.; Park, J. H.; Curran, K. J.; Smith, E.; Pegram, H. J.; Brentjens, R. |
| Article Title: | Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies |
| Abstract: | The genetic modification of autologous T cells with chimeric antigen receptors (CARs) represents a breakthrough for gene engineering as a cancer therapy for hematologic malignancies. By targeting the CD19 antigen, we have demonstrated robust and rapid anti-leukemia activity in patients with heavily pre-treated and chemotherapy-refractory B cell acute lymphoblastic leukemia (B-ALL). We demonstrated rapid induction of deep molecular remissions in adults, which has been recently confirmed in a case report involving a child with B-ALL. In contrast to the results when treating B-ALL, outcomes have been more modest in patients with chronic lymphocytic leukemia (CLL) or other non-hodgkin's lymphoma (NHL). We review the clinical trial experience targeting B-ALL and CLL and speculate on the possible reasons for the different outcomes and propose potential optimization to CAR T cell therapy when targeting CLL or other indolent NHL. Lastly, we discuss the pre-clinical development and potential for clinical translation for using CAR T cells against multiple myeloma and acute myeloid leukemia. We highlight the potential risks and benefits by targeting these poor outcome hematologic malignancies. © 2013 The Japanese Society of Hematology. |
| Keywords: | hematologic malignancies; car; adoptive t cell therapy |
| Journal Title: | International Journal of Hematology |
| Volume: | 99 |
| Issue: | 4 |
| ISSN: | 0925-5710 |
| Publisher: | Springer Japan KK |
| Date Published: | 2014-04-01 |
| Start Page: | 361 |
| End Page: | 371 |
| Language: | English |
| DOI: | 10.1007/s12185-013-1479-5 |
| PROVIDER: | scopus |
| PUBMED: | 24311149 |
| PMCID: | PMC4684946 |
| DOI/URL: | |
| Notes: | Int. J. Hematol. -- Cited By (since 1996):1 -- Export Date: 2 June 2014 -- CODEN: IJHEE -- Source: Scopus |
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