Abstract: |
Patients with Hodgkin lymphoma (HL) who remain refractory to their chemotherapy-based primary treatment or relapse after obtaining a remission still have a very good chance of cure with appropriate salvage therapy. Most will be good candidates for high-dose therapy (HDT) programs that are supported with infusion of their autologous peripheral blood stem cells. Most programs start with standard-dose chemotherapy for response re-induction in an attempt to maximize tumor reduction prior to HDT. In special circumstances, other salvage options with standard-dose chemotherapy and/or radiation therapy (RT) are available and are also discussed below. Radiation therapy should play a major role in the salvage effort of chemotherapy or combined-modality failures, as often its benefits have not been exploited with the primary treatment. Methods of integrating RT effectively and safely into the salvage effort are discussed in this chapter. © 2011 Springer-Verlag Berlin Heidelberg. |