Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS) Journal Article
| Authors: | Simpson, T. R.; Quezada, S. A.; Allison, J. P. |
| Article Title: | Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS) |
| Abstract: | Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is upregulated on the surface of T cells following T cell activation and upon binding to its ligand (ICOSL), initiates a cascade of events that can shape key aspects of the immune response. Although initial studies focused on determining the role of ICOS in Th1 versus T helper 2 (Th2) responses, new insights into its biology have revealed the contribution of ICOS to germinal center formation and isotype switching, as well as its relevance to the fate and function of effector and regulatory CD4+ T cells in the response against self (i.e., tumors) and non-self (i.e., bacterial, worm, and viral infections). This multiplicity of roles positions ICOS at the center of attention for immunotherapy where manipulation of this pathway could lead to novel approaches in the treatment of human diseases. © 2010 Elsevier Ltd. |
| Keywords: | unclassified drug; review; nonhuman; cell proliferation; animals; mice; mice, knockout; cell survival; gene targeting; cytotoxic t lymphocyte antigen 4 antibody; melanoma; gene expression; transforming growth factor beta; interleukin 4; gene function; cell differentiation; b lymphocyte; cell lineage; monoclonal antibody; gene expression regulation; immunological tolerance; th2 cell; lymphocyte activation; immune response; regulatory mechanism; immunotherapy; gamma interferon; cd4+ t lymphocyte; cd4-positive t-lymphocytes; ligands; systemic lupus erythematosus; upregulation; th1 cell; cytokine release; autoimmune disease; ligand binding; t lymphocyte activation; cd28 antigen; helper cell; interferon regulatory factor 4; memory t lymphocyte; antigens, differentiation, t-lymphocyte; inducible costimulator; inducible costimulator ligand antibody; autoimmune encephalitis; lupus erythematosus nephritis; pharmacological blocking |
| Journal Title: | Current Opinion in Immunology |
| Volume: | 22 |
| Issue: | 3 |
| ISSN: | 0952-7915 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-06-01 |
| Start Page: | 326 |
| End Page: | 332 |
| Language: | English |
| DOI: | 10.1016/j.coi.2010.01.001 |
| PUBMED: | 20116985 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: COPIE" - "Source: Scopus" |
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