The prognostic impact of isolated tumor cells in lymph nodes of T2N0 gastric cancer: Comparison of American and Japanese gastric cancer patients Journal Article


Authors: Fukagawa, T.; Sasako, M.; Shimoda, T.; Sano, T.; Katai, H.; Saka, M.; Mann, G. B.; Karpeh, M.; Coit, D. G.; Brennan, M. F.
Article Title: The prognostic impact of isolated tumor cells in lymph nodes of T2N0 gastric cancer: Comparison of American and Japanese gastric cancer patients
Abstract: Background: The clinical significance of immunohistochemically detected isolated tumor cells (ITC) in lymph nodes of gastric cancer patients is controversial. This study examined the prognostic impact of ITC on patients with early-stage gastric cancer in two large volume centers in the United States and Japan. Methods: Fifty-seven patients with T2N0M0 gastric carcinoma who underwent gastric resection between January 1987 and January 1997 at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York and 107 patients resected at National Cancer Center Hospital (NCCH) in Tokyo between January 1984 and December 1990 were studied. The sections were newly prepared from each lymph node for immunohistochemical staining for cytokeratin. Lymph nodes and original specimens from MSKCC were examined by pathologists in NCCH. The prognostic significance of the presence of ITC in lymph nodes was investigated in patients of both institutions. Results: ITC were identified in 30 of 57 patients (52.6%) at MSKCC and in 38 of 107 patients (35.5%) at NCCH. In both institutions, there was no significant difference in the prognosis of the studied patients with or without ITC (P = .22, .86 respectively). Conclusions: The presence of ITC detected by immunohistochemistry in the regional lymph nodes did not affect the prognosis of American and Japanese patients with T2N0M0 gastric carcinoma who underwent gastrectomy with D2 lymph node dissection. © 2009 Society of Surgical Oncology.
Keywords: adult; controlled study; human tissue; aged; aged, 80 and over; middle aged; cancer surgery; survival rate; human cell; major clinical study; united states; follow-up studies; lymph nodes; lymphatic metastasis; neoplasm staging; cancer grading; lymph node excision; sentinel lymph node biopsy; adenocarcinoma; neoplasm recurrence, local; tumor markers, biological; risk factors; cell differentiation; immunoenzyme techniques; neoplastic cells, circulating; lymph node; tumor cell; cell isolation; gastrectomy; neoplasm invasiveness; keratins; race difference; american; ethnic group; japanese; stomach carcinoma; japan; stomach neoplasms
Journal Title: Annals of Surgical Oncology
Volume: 16
Issue: 3
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2009-03-01
Start Page: 609
End Page: 613
Language: English
DOI: 10.1245/s10434-008-0290-7
PUBMED: 19137375
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: ASONF" - "Source: Scopus"
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MSK Authors
  1. Murray F Brennan
    814 Brennan
  2. Daniel Coit
    432 Coit