Upper gastrointestinal cancer predisposition syndromes Journal Article
| Authors: | Shah, M. A.; Kurtz, R. C. |
| Article Title: | Upper gastrointestinal cancer predisposition syndromes |
| Abstract: | Malignancies of the upper gastrointestinal tract form a heterogeneous group of cancers characterized by unique epidemiology and biology. Despite these differences, survival for advanced disease remains poor across the panel of diseases, from cancers of the esophagus, stomach, pancreas, and, until recently, even gastrointestinal stromal tumors. Genetic predisposition syndromes associated with these diseases comprise an emerging subset of these diseases that may provide valuable information on cause and etiology. They may provide insight into molecular drivers for the disease, or disease subtypes, and also insights into novel gene/environment interactions. This review summarizes the current understanding of genetic predisposition syndromes of cancers of the upper gastrointestinal tract. © 2010 Elsevier Inc. |
| Keywords: | gene deletion; missense mutation; pathogenesis; review; cancer risk; pancreas cancer; cancer incidence; gastrointestinal stromal tumor; cancer susceptibility; disease association; genetic predisposition to disease; amino acid substitution; genetic association; obesity; genetic transcription; brca2 protein; uvomorulin; cancer mortality; carcinogenesis; digestive system cancer; gastrointestinal neoplasms; microsatellite instability; family history; gene interaction; pancreatitis; stomach cancer; familial cancer; malignancy; methylated dna protein cysteine methyltransferase; cyclin dependent kinase inhibitor 2a; genetic risk; esophagus cancer; esophageal adenocarcinoma; environmental factor; genetic predisposition; protein mlh1; protein msh2; esophagus carcinoma; upper gastrointestinal tract; arginine; histidine; genetic testing; genetic linkage; chromosome 16q; esophageal squamous cell carcinoma; hereditary; genetic polymorphism; penetrance; hereditary nonpolyposis colorectal cancer; oncogene c kit; linkage analysis; neoplastic syndromes, hereditary; gastrointestinal; barrett esophagus; helicobacter infection; brca1 associated ring domain protein 1; cytoglobin; familial atypical multiple mole melanoma syndrome; familial colon polyposis; hereditary diffuse gastric cancer; peutz jeghers syndrome; tylosis |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-10-01 |
| Start Page: | 815 |
| End Page: | 835 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2010.06.007 |
| PUBMED: | 20816576 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: HCNAE" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work