SGO white paper on ovarian cancer: Etiology, screening and surveillance Journal Article
| Authors: | Schorge, J. O.; Modesitt, S. C.; Coleman, R. L.; Cohn, D. E.; Kauff, N. D.; Duska, L. R.; Herzog, T. J. |
| Article Title: | SGO white paper on ovarian cancer: Etiology, screening and surveillance |
| Abstract: | Ovarian cancer is a heterogeneous, rapidly progressive, highly lethal disease of low prevalence. The etiology remains poorly understood. Numerous risk factors have been identified, the most prominent involving an inherited predisposition in 10% of cases. Women with germline mutations associated with Hereditary Breast/Ovarian Cancer and Lynch syndromes have dramatically elevated risks (up to 46% and 12%, respectively). Risk-reducing salpingo-oophorectomy is the best method to prevent ovarian cancer in these high-risk women. Significant risk reduction is also seen in the general population who use oral contraceptives. Since up to 89% patients with early-stage disease have symptoms prior to diagnosis, increased awareness of the medical community may facilitate further workup in patients who otherwise would have had a delay. Despite enormous effort, there is no proof that routine screening for ovarian cancer in either the high-risk or general populations with serum markers, sonograms, or pelvic examinations decreases mortality. Further evaluation is needed to determine whether any novel biomarkers, or panels of markers, have clinical utility in early detection. Prospective clinical trials have to be designed and completed prior to offering of any of these new diagnostic tests. CA125 is currently the only biomarker recommended for monitoring of therapy as well as detection of recurrence. This commentary provides an overview on the background, screening and surveillance of ovarian cancer. © 2010 Elsevier Inc. |
| Keywords: | protein kinase b; cancer chemotherapy; protein expression; cancer surgery; gene mutation; androgen; review; cancer recurrence; cancer risk; cancer staging; cancer diagnosis; diagnostic accuracy; endometrium cancer; salpingooophorectomy; sensitivity and specificity; antigen expression; cytoreductive surgery; ovarian neoplasms; leptin; allele; dna damage; cell division; cancer susceptibility; gene overexpression; apoptosis; peritoneum cancer; breast cancer; carcinoembryonic antigen; epidermal growth factor receptor 2; inflammation; estrogen; genetic variability; cancer screening; mass screening; food and drug administration; brca1 protein; brca2 protein; proteomics; protein p53; risk factor; cancer mortality; gonadotropin; menarche; abdominal pain; europe; axillary lymph node; oncogene; tumor suppressor gene; double stranded dna; early diagnosis; colonoscopy; colon cancer; microsatellite instability; family history; cancer size; predictive validity; computer assisted emission tomography; ovary carcinoma; tamoxifen; double stranded dna break; pregnancy; pleura effusion; pelvis pain syndrome; cancer epidemiology; high risk population; inguinal lymph node; ca 125 antigen; uterine tube carcinoma; oncogene k ras; premenopause; menopause; k ras protein; race difference; japan; protein mlh1; protein msh2; united kingdom; b raf kinase; north america; somatomedin b; genetic counseling; endometrium biopsy; mesothelin; hormone substitution; lactation; follitropin; hormone synthesis; endometriosis; female infertility; hereditary nonpolyposis colorectal cancer; muellerian duct; surface enhanced laser desorption ionization time of flight mass spectrometry; matrilysin; prolactin; gestagen; progesterone; bloating; luteinizing hormone; ovary polycystic disease; transvaginal echography; osteopontin; hereditary breast ovarian cancer syndrome; ovarian cancer screening; risk-reducing salpingo-oophorectomy; apolipoprotein e; hla g antigen; macrophage migration inhibition factor; auscultation; eating disorder; gonadotropin release; hungary; iceland; nullipara; superovulation |
| Journal Title: | Gynecologic Oncology |
| Volume: | 119 |
| Issue: | 1 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-10-01 |
| Start Page: | 7 |
| End Page: | 18 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2010.06.003 |
| PUBMED: | 20692025 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: GYNOA" - "Source: Scopus" |
