The oncogenic role of the ETS transcription factors MEF and ERG Journal Article
| Authors: | Sashida, G.; Bazzoli, E.; Menendez, S.; Liu, Y.; Nimer, S. D. |
| Article Title: | The oncogenic role of the ETS transcription factors MEF and ERG |
| Abstract: | Several ETS transcription factors, including MEF/ELF4 and ERG, can function as oncogenes and are overexpressed in human cancer. MEF cooperates in tumorigenesis in retroviral insertional mutagenesis-based mouse models of cancer and MEF is overexpressed in human lymphoma and ovarian cancer tissues via unknown mechanisms. ERG (Ets related gene) overexpression or increased activity has been found in various human cancers, including sarcomas, acute myeloid leukemia and prostate cancer, where the ERG gene is rearranged due to chromosomal translocations. We have been examining how MEF functions as an oncogene and recently showed that MEF can cooperate with H-RasG12v and can inhibit both p53 and p16 expression thereby promoting transformation. in fact, in cells lacking p53, the absence of Mef abrogates H-Ras G12v-induced transformation of mouse embryonic fibroblasts, at least in part due to increased p16 expression. We discuss the known mechanisms by which the ETS transcription factors MEF and ERG contribute to the malignant transformation of cells. © 2010 Landes Bioscience. |
| Keywords: | protein expression; unclassified drug; acute granulocytic leukemia; dna-binding proteins; review; neoplasms; gene overexpression; protein p16; ovary cancer; protein p53; oncogene h ras; carcinogenesis; transcription factors; prostate cancer; sarcoma; oncogene; lymphoma; transcription factor erg; fibroblast; tumor suppressor protein p53; chromosome translocation; trans-activators; ras proteins; malignant transformation; mutagenesis; ras; p53; transcription factor ets; proto-oncogene proteins c-mdm2; mdm2; aml; aml1-eto; myeloid elf1 like factor; ets related gene; proto-oncogene proteins c-ets |
| Journal Title: | Cell Cycle |
| Volume: | 9 |
| Issue: | 17 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2010-09-01 |
| Start Page: | 3457 |
| End Page: | 3459 |
| Language: | English |
| DOI: | 10.4161/cc.9.17.13000 |
| PUBMED: | 20814243 |
| PROVIDER: | scopus |
| PMCID: | PMC3230474 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Source: Scopus" |
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