Ovarian cancer: The role of functional imaging as an end point in clinical trials Journal Article
| Authors: | Sala, E.; DeSouza, N.; Lee, S. I.; Atri, M.; Hricak, H. |
| Article Title: | Ovarian cancer: The role of functional imaging as an end point in clinical trials |
| Abstract: | The Gynaecological Cancer InterGroup conducts collaborative trials in gynecologic cancer and also aims to develop standards that can be used to strengthen all aspects of study methodology. There is an urgent need to develop more refined imaging end points that can be used as early treatment response biomarkers in ovarian cancer. Therefore, the Gynaecological Cancer InterGroup commissioned an expert position paper on the role of functional imaging as an end point in clinical trials in ovarian cancer. In this position paper, we state the limitation of current anatomical imaging methods used in clinical trials, highlight the potential of functional imaging, and provide key recommendations on the use of functional imaging as an end point in ovarian cancer clinical trials. Copyright © 2010 by IGCS and ESGO. |
| Keywords: | clinical trial; review; nuclear magnetic resonance imaging; positron emission tomography; magnetic resonance imaging; sensitivity analysis; ovarian cancer; ovarian neoplasms; computer assisted tomography; ovary cancer; tumor volume; tumor markers, biological; tomography, x-ray computed; diagnostic imaging; biomarker; contrast enhancement; echography; fluorodeoxyglucose f 18; positron-emission tomography; practice guidelines as topic; forecasting; imaging; contrast media; ca-125 antigen; diffusion weighted imaging; needs assessment; ultrasonography, doppler; functional imaging; radiographic image enhancement |
| Journal Title: | International Journal of Gynecological Cancer |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 1048-891X |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2010-08-01 |
| Start Page: | 971 |
| End Page: | 978 |
| Language: | English |
| DOI: | 10.1111/IGC.0b013e3181e0a353 |
| PUBMED: | 20683404 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: IJGCE" - "Source: Scopus" |
