Outcomes in patients with poorly differentiated thyroid carcinoma Journal Article
| Authors: | Ibrahimpasic, T.; Ghossein, R.; Carlson, D. L.; Nixon, I.; Palmer, F. L.; Shaha, A. R.; Patel, S. G.; Tuttle, R. M.; Shah, J. P.; Ganly, I. |
| Article Title: | Outcomes in patients with poorly differentiated thyroid carcinoma |
| Abstract: | Background: Poorly differentiated thyroid cancer (PDTC) accounts for only 1-15% of all thyroid cancers. Our objective is to report outcomes in a large series of patients with PDTC treated at a single tertiary care cancer center. Methods: A total of 91 patients with primary PDTC were treated by initial surgery with or without adjuvant therapy at Memorial Sloan-Kettering Cancer Center from 1986 to 2009. Outcomes were calculated by the Kaplan-Meier method. Clinicopathological characteristics were compared for PDTC patients who died of disease to those who did not by the 2 test. Factors predictive of disease-specific survival (DSS) were calculated by univariate and multivariate analysis using the log rank and Cox proportional hazards method, respectively. Results: With a median follow-up of 50 months, the 5-year overall survival and DSS were 62 and 66%, respectively. The 5-year locoregional and distant control were 81 and 59%, respectively. Of 27 disease-specific deaths, 23 (85%) were due to distant disease. Age - 45 years, pathological tumor size 4 cm, extrathyroidal extension, higher pathological T stage, positive margins, and distant metastases (M1) were predictive of worse DSS on univariate analysis. Multivariate analysis showed that only pT4a stage and M1 were independent predictors of worse DSS. Conclusions: With appropriate surgery and adjuvant therapy, excellent locoregional control can be achieved in PDTC. Disease-specific deaths occurred due to distant metastases and rarely due to uncontrolled locoregional recurrence in this series. Copyright © 2014 by the Endocrine Society. |
| Journal Title: | Journal of Clinical Endocrinology and Metabolism |
| Volume: | 99 |
| Issue: | 4 |
| ISSN: | 0021-972X |
| Publisher: | Oxford University Press |
| Date Published: | 2014-04-01 |
| Start Page: | 1245 |
| End Page: | 1252 |
| Language: | English |
| DOI: | 10.1210/jc.2013-3842 |
| PROVIDER: | scopus |
| PUBMED: | 24512493 |
| DOI/URL: | |
| Notes: | Cited By (since 1996):1 -- Export Date: 1 May 2014 -- CODEN: JCEMA -- Source: Scopus |
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