Regulation of Ku-DNA association by yku70 C-terminal tail and SUMO modification Journal Article

   


Authors: Hang, L. E.; Lopez, C. R.; Liu, X.; Williams, J. M.; Chung, I.; Wei, L.; Bertuch, A. A.; Zhao, X.
Article Title: Regulation of Ku-DNA association by yku70 C-terminal tail and SUMO modification
Abstract: Background: The Ku70-Ku80 ring encloses DNA ends to enable telomere protection and DNA repair. Results: Conditional sumoylation of Ku70 is reduced by mutating C-terminal lysines and this mutant shows decreased DNA interaction, shortened telomeres, and altered DNA repair. Conclusion: Our analyses suggest that sumoylation modulates Ku function by enhancing its DNA association. Significance: Ku is regulated by Ku70 C-terminal lysines and SUMO modification.© 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
Journal Title: Journal of Biological Chemistry
Volume: 289
Issue: 15
ISSN: 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology  
Date Published: 2014-04-11
Start Page: 10308
End Page: 10317
Language: English
DOI: 10.1074/jbc.M113.526178
PROVIDER: scopus
PMCID: PMC4036155
PUBMED: 24567323
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84898619525&partnerID=40&md5=0e0d080c4f3429f2cf7d4cf37feb82aa
Notes: Export Date: 1 May 2014 -- CODEN: JBCHA -- Source: Scopus
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MSK Authors
  1. Xiaolan Zhao
    77 Zhao
  2. Xianpeng Liu
    5 Liu
  3. Lisa Eileen Hang
    9 Hang
  4. Inn Chung
    5 Chung
  5. Lei Wei
    11 Wei
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