Metabolic interactions between vitamin A and conjugated linoleic acid Journal Article
| Authors: | Carta, G.; Murru, E.; Cordeddu, L.; Ortiz, B.; Giordano, E.; Belury, M. A.; Quadro, L.; Banni, S. |
| Article Title: | Metabolic interactions between vitamin A and conjugated linoleic acid |
| Abstract: | Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR-α and RXR heterodimer. We also present preliminary data that may position PPAR-α at the crossroads between the metabolism of lipids and vitamin A. © 2014 by the authors; licensee MDPI, Basel, Switzerland. |
| Keywords: | protein expression; review; nonhuman; protein blood level; biosynthesis; messenger rna; drug tissue level; drug metabolism; retinol; dietary intake; homeostasis; ic 50; peroxisome proliferator activated receptor gamma; beta carotene; prealbumin; cytochrome p450; metabolic regulation; vitamin a; nonalcoholic fatty liver; retinoid x receptor; receptor activator of nuclear factor kappa b; vitamin metabolism; lipolysis; conjugated linoleic acid (cla); oleoylethanolamide (oea); palmitoylethanolamide (pea); peroxisome proliferator-activated receptor-alpha (ppara); retinol binding protein (rbp); conjugated linoleic acid; g protein coupled receptor 40; n oleoylethanolamine; palmidrol; peroxisome proliferator activated receptor alpha; retinol binding protein 4; vanilloid receptor 1 |
| Journal Title: | Nutrients |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 2072-6643 |
| Publisher: | MPDI AG |
| Date Published: | 2014-03-24 |
| Start Page: | 1262 |
| End Page: | 1272 |
| Language: | English |
| DOI: | 10.3390/nu6031262 |
| PROVIDER: | scopus |
| PMCID: | PMC3967192 |
| PUBMED: | 24667133 |
| DOI/URL: | |
| Notes: | Export Date: 1 May 2014 -- Source: Scopus |
