Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography. Ready for prime time? Journal Article
| Authors: | Rudd, J. H. F.; Narula, J.; Strauss, H. W.; Virmani, R.; Machac, J.; Klimas, M.; Tahara, N.; Fuster, V.; Warburton, E. A.; Fayad, Z. A.; Tawakol, A. A. |
| Article Title: | Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography. Ready for prime time? |
| Abstract: | Inflammation is a determinant of atherosclerotic plaque rupture, the event leading to most myocardial infarctions and strokes. Although conventional imaging techniques identify the site and severity of luminal stenosis, the inflammatory status of the plaque is not addressed. Positron emission tomography imaging of atherosclerosis using the metabolic marker fluorodeoxyglucose allows quantification of arterial inflammation across multiple vessels. This review sets out the background and current and potential future applications of this emerging biomarker of cardiovascular risk, along with its limitations. © 2010 American College of Cardiology Foundation. |
| Keywords: | immunohistochemistry; review; nonhuman; nuclear magnetic resonance imaging; positron emission tomography; sensitivity and specificity; reproducibility; animals; computer assisted tomography; cohort studies; cell infiltration; inflammation; enzyme activity; molecular imaging; severity of illness index; drug uptake; biopsy, needle; cardiovascular risk; atherosclerosis; cell membrane; fluorodeoxyglucose f18; positron-emission tomography; imaging; protein dephosphorylation; disease models, animal; image processing, computer-assisted; macrophage; phagocytosis; cell activation; glucose transporter 3; simvastatin; atherosclerotic plaque; coronary artery disease; cell motility; fluorodeoxyglucose; angiography; glucose transporter 1; radiographic image enhancement; glucose metabolism; glucose transporter; glucose transporter 4; arteries |
| Journal Title: | Journal of the American College of Cardiology |
| Volume: | 55 |
| Issue: | 23 |
| ISSN: | 0735-1097 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2010-06-08 |
| Start Page: | 2527 |
| End Page: | 2535 |
| Language: | English |
| DOI: | 10.1016/j.jacc.2009.12.061 |
| PUBMED: | 20513592 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 20 April 2011" - "CODEN: JACCD" - "Source: Scopus" |
