Cracking the NF-κB code Journal Article
| Authors: | Tkach, K. E.; Oyler, J. E.; Altan-Bonnet, G. |
| Article Title: | Cracking the NF-κB code |
| Abstract: | The discovery of feedback loops between signaling and gene expression is ushering in new quantitative models of cellular regulation. In a recent issue of Science Signaling, Sung et al. showed how positive feedback downstream of nuclear factor κB (NF-κB) signaling enhances the capacity of macrophages to scale their antimicrobial responses to the dose of pathogen-associated molecular cues. This fi nding stemmed from analysis of cell-to-cell variability and computational modeling of time integration between signaling and transcriptional responses. Ultimately, such quantitative approaches challenge the oft-assumed time separation of "fast" signal transduction followed by "slow" gene expression, and they provide a better understanding of complex biological regulation over long time scales. |
| Journal Title: | Science Signaling |
| Volume: | 7 |
| Issue: | 313 |
| ISSN: | 1945-0877 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2014-02-18 |
| Start Page: | pe5 |
| Language: | English |
| DOI: | 10.1126/scisignal.2005108 |
| PROVIDER: | scopus |
| PUBMED: | 24550540 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2014 -- Source: Scopus |
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Oyler
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