Prognostic significance of the highest peripancreatic lymph node in biliary tract adenocarcinoma Journal Article


Authors: Kelly, K. J.; Dukleska, K.; Kuk, D.; Kingham, T. P.; D'Angelica, M. I.; DeMatteo, R. P.; Allen, P. J.; Jarnagin, W. R.; Fong, Y.
Article Title: Prognostic significance of the highest peripancreatic lymph node in biliary tract adenocarcinoma
Abstract: Background: Patients with biliary tract adenocarcinoma with nodal involvement have a poor prognosis. There is currently no standardized method for intraoperative lymph node assessment. The current study aimed to determine the prognostic significance of the highest peripancreatic lymph node (HPLN) in biliary tract malignancy. Methods: This was a retrospective study of patients undergoing potential curative resection of biliary tract adenocarcinoma from January 1995 through December 2010 who prospectively had intraoperative sampling of the HPLN. The median follow-up was 72.8 months. The primary end points were recurrence-free survival (RFS) and disease-specific survival (DSS). Results: The rate of HPLN positivity in 110 patients undergoing exploration for potential curative resection was 30 % and did not vary with histologic subtype (gallbladder vs. cholangiocarcinoma). Eighty-five patients underwent complete gross resection. In this subset, median RFS and DSS were 34.3 months (95 % confidence interval [CI] 23.6 - not reached [NR]) and 62.4 months (95 % CI 40.8 - NR) for HPLN-negative patients, and 9.6 months (95 % CI 4.76 - NR) and 20.5 months (95 % CI 7.4 - NR) for HPLN-positive patients (p < 0.01), respectively. Median DSS was 14.6 months (95 % CI 9.6-25.4) for patients with unresectable disease. On multivariate analysis, HPLN status was an independent predictor of RFS (hazard ratio 3.73, 95 % CI 1.86-7.45; p < 0.01) and DSS (hazard ratio 3.98, 95 % CI 1.89-8.38; p < 0.01). Conclusions: HPLN status is prognostic of RFS and DSS in biliary tract adenocarcinoma. Intraoperative nodal staging by HPLN sampling warrants further investigation in a prospective trial. © 2013 Society of Surgical Oncology.
Keywords: adult; cancer survival; human tissue; aged; middle aged; cancer surgery; major clinical study; histopathology; cancer patient; follow up; retrospective study; lymph node; predictor variable; bile duct carcinoma; biliary tract surgery; disease specific survival; predictive value; recurrence free survival; gallbladder; cancer prognosis; very elderly; human; male; female; article; highest peripancreatic lymph node
Journal Title: Annals of Surgical Oncology
Volume: 21
Issue: 3
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2014-03-01
Start Page: 979
End Page: 985
Language: English
DOI: 10.1245/s10434-013-3352-4
PROVIDER: scopus
PUBMED: 24212720
PMCID: PMC4733850
DOI/URL:
Notes: Export Date: 2 April 2014 -- CODEN: ASONF -- Source: Scopus
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MSK Authors
  1. Ronald P DeMatteo
    605 DeMatteo
  2. Kaitlyn J Kelly
    28 Kelly
  3. Peter Allen
    445 Allen
  4. William R Jarnagin
    598 Jarnagin
  5. Yuman Fong
    746 Fong
  6. T Peter Kingham
    295 Kingham
  7. Deborah Kuk
    81 Kuk