The IL-6 feed-forward loop: A driver of tumorigenesis Journal Article

  


Authors: Chang, Q.; Daly, L.; Bromberg, J.
Article Title: The IL-6 feed-forward loop: A driver of tumorigenesis
Abstract: IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this signaling pathway. Although blockade of this pathway in pre-clinical models leads to a reduction in tumor growth and metastasis, its clinical success is less evident. Thus, identifying the features of tumors/patients that predict response to anti-IL6 therapy are needed. © 2014.
Keywords: metastasis; microenvironment; cancer
Journal Title: Seminars in Immunology
Volume: 26
Issue: 1
ISSN: 1044-5323
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 2014-02-01
Start Page: 48
End Page: 53
Language: English
DOI: 10.1016/j.smim.2014.01.007
PROVIDER: scopus
PUBMED: 24613573
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84896491618&partnerID=40&md5=840535a8be882e3f9a21210f597ca8f1
Notes: Export Date: 2 April 2014 -- CODEN: SEIME -- Source: Scopus
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MSK Authors
  1. Jacqueline Bromberg
    141 Bromberg
  2. Qing Chang
    36 Chang
  3. Laura Daly
    11 Daly
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