Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs Journal Article


Authors: Park, S. M.; Deering, R. P.; Lu, Y.; Tivnan, P.; Lianoglou, S.; Al-Shahrour, F.; Ebert, B. L.; Hacohen, N.; Leslie, C.; Daley, G. Q.; Lengner, C. J.; Kharas, M. G.
Article Title: Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs
Abstract: Hematopoietic stem cells (HSCs) are maintained through the regulation of symmetric and asymmetric cell division. We report that conditional ablation of the RNA-binding protein Msi2 results in a failure of HSC maintenance and engraftment caused by a loss of quiescence and increased commitment divisions. Contrary to previous studies, we found that these phenotypes were independent of Numb. Global transcriptome profiling and RNA target analysis uncovered Msi2 interactions at multiple nodes within pathways that govern RNA translation, stem cell function, and TGF-β signaling. Msi2-null HSCs are insensitive to TGF-β-mediated expansion and have decreased signaling output, resulting in a loss of myeloid-restricted HSCs and myeloid reconstitution. Thus, Msi2 is an important regulator of the HSC translatome and balances HSC homeostasis and lineage bias. © 2014 Park et al.
Journal Title: Journal of Experimental Medicine
Volume: 211
Issue: 1
ISSN: 0022-1007
Publisher: Rockefeller University Press  
Date Published: 2014-01-13
Start Page: 71
End Page: 87
Language: English
DOI: 10.1084/jem.20130736
PROVIDER: scopus
PMCID: PMC3892968
PUBMED: 24395885
DOI/URL:
Notes: Export Date: 3 March 2014 -- CODEN: JEMEA -- Source: Scopus
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MSK Authors
  1. Christina Leslie
    106 Leslie
  2. Patrick Edward Tivnan
    10 Tivnan
  3. Michael Kharas
    44 Kharas
  4. Sun Mi Park
    12 Park
  5. Yuheng Lu
    11 Lu