TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1 Journal Article
| Authors: | Liu, Y.; Raheja, R.; Yeh, N.; Ciznadija, D.; Pedraza, A. M.; Ozawa, T.; Hukkelhoven, E.; Erdjument-Bromage, H.; Tempst, P.; Gauthier, N. P.; Brennan, C.; Holland, E. C.; Koff, A. |
| Article Title: | TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1 |
| Abstract: | The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor-induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21 WAF1/CIP1. Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4. © 2014 Macmillan Publishers Limited. |
| Keywords: | glioma; p21; pdgf; stem/progenitor; trim3 |
| Journal Title: | Oncogene |
| Volume: | 33 |
| Issue: | 3 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2014-01-16 |
| Start Page: | 308 |
| End Page: | 315 |
| Language: | English |
| DOI: | 10.1038/onc.2012.596 |
| PROVIDER: | scopus |
| PMCID: | PMC3928554 |
| PUBMED: | 23318451 |
| DOI/URL: | |
| Notes: | Export Date: 3 March 2014 -- CODEN: ONCNE -- Source: Scopus |
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